6226-25-1 Usage
Description
2,2,2-Trifluoroethyl trifluoromethanesulfonate is a fluorine-containing alkyl alkanesulfonate that exhibits cytotoxicity towards cultured leukemia L1210 cells. It is a powerful trifluoroethylating agent, making it useful for the synthesis of fluorinated amino acids.
Uses
Used in Pharmaceutical Industry:
2,2,2-Trifluoroethyl trifluoromethanesulfonate is used as a reagent in the enantioselective preparation of cyclic N-aryl hydroxamic acids via phase-transfer catalyzed alkylation of nitrobenzyl bromides to give nirophenylalanines. This application is significant in the development of pharmaceutical compounds with potential therapeutic applications.
Used in Organic Synthesis:
2,2,2-Trifluoroethyl trifluoromethanesulfonate is utilized as a powerful trifluoroethylating agent in the synthesis of fluorinated amino acids. This is important for the development of novel compounds with unique properties and potential applications in various fields, including medicine and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 6226-25-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,2,2 and 6 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 6226-25:
(6*6)+(5*2)+(4*2)+(3*6)+(2*2)+(1*5)=81
81 % 10 = 1
So 6226-25-1 is a valid CAS Registry Number.
InChI:InChI=1/C3H2F6O3S/c4-2(5,6)1-12-13(10,11)3(7,8)9/h1H2
6226-25-1Relevant articles and documents
METHOD FOR PRODUCTION OF FLUOROALYKYLFLUOROALKANE-SULFONATE
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Page/Page column 11; 13, (2008/06/13)
PROBLEM TO BE SOLVED: To provide a method for simply producing, under more moderate condition than heretofore, a fluoroalkylfluoroalkane-sulfonate useful as an intermediate for medicines or agrochemicals and as a reagent for introducing a fluorine-containing group. SOLUTION: The fluoroalkyl fluoroalkane-sulfonate is produced by reacting a perfluoroalkanesulfonyl halide with a fluorine-containing alcohol in the presence of a base. In this case, an organic solvent is not used but water coexists as a solvent. It is particularly preferable that a reaction temperature is ≥-10°C but ≤40°C and water content is ≥0.2 g and ≤5 g per 1 g of the fluorine-containing alcohol. According to this method, for example, 2,2,2-trifluoroethyltrifluoromethane-sulfonate or 2,2,3,3-tetrafluoropropyltrifluoromethane-sulfonate can efficiently be produced, and the discharge amount of waste materials can remarkably be reduced. COPYRIGHT: (C)2006,JPOandNCIPI
