622801-34-7Relevant articles and documents
Synthetic dihydropacidamycin antibiotics: A modified spectrum of activity for the pacidamycin class
Boojamra, Constantine G.,Lemoine, Remy C.,Blais, Johanne,Vernier, Nicole G.,Stein, Karin A.,Magon, Angela,Chamberland, Suzanne,Hecker, Scott J.,Lee, Ving J.
, p. 3305 - 3309 (2007/10/03)
Dihydropacidamycins having an antibacterial spectrum modified from that of the natural product pacidamycins and mureidomycins have been synthesized. Synthetic dihydropacidamycins with noteworthy antibacterial activity against wild-type and resistant Escherichia coli have been identified (MIC=4-8 μg/mL). Some dihydropacidamycins are shown to have activity against multi-resistant clinical strains of Mycobacterium tuberculosis. Compounds of this class are inhibitors of the cell wall biosynthetic enzyme, MraY.