62396-98-9Relevant articles and documents
Diazotrifluoroethyl Radical: A CF3-Containing Building Block in [3 + 2] Cycloaddition
Zhao, Wen-Wen,Shao, Yong-Chao,Wang, An-Ni,Huang, Jia-Li,He, Chun-Yang,Cui, Bao-Dong,Wan, Nan-Wei,Chen, Yong-Zheng,Han, Wen-Yong
supporting information, p. 9256 - 9261 (2021/12/06)
We present herein a visible-light-induced [3 + 2] cycloaddition of a hypervalent iodine(III) reagent with α-ketoacids for the construction of 5-CF3-1,3,4-oxadiazoles that are of importance in medicinal chemistry. The reaction proceeds smoothly without a photocatalyst, metal, or additive under mild conditions. Different from the well-established trifluorodiazoethane (CF3CHN2), the diazotrifluoroethyl radical [CF3C(·)N2], a trifluoroethylcarbyne (CF3C?:) equivalent and an unusual CF3-containing building block, is involved in the present reaction system.
Pd(OAc)2-Catalyzed Asymmetric Hydrogenation of α-Iminoesters
Chen, Jianzhong,Li, Feilong,Wang, Fang,Hu, Yawen,Zhang, Zhenfeng,Zhao, Min,Zhang, Wanbin
supporting information, p. 9060 - 9065 (2019/11/19)
An efficient Pd(OAc)2-catalyzed asymmetric hydrogenation of α-iminoesters was realized for the first time at 1 atm hydrogen pressure and room temperature. Pd(OAc)2, a less expensive Pd salt with low toxicity, was found to be the most suitable catalyst precursor rather than Pd(TFA)2 which is usually the catalyst of choice for homogeneous asymmetric hydrogenation. The chiral α-arylglycine fragments are widely found in many chiral products and bioactive molecules.
Direct Acyl Radical Addition to 2 H-Indazoles Using Ag-Catalyzed Decarboxylative Cross-Coupling of α-Keto Acids
Bogonda, Ganganna,Kim, Hun Young,Oh, Kyungsoo
supporting information, p. 2711 - 2715 (2018/05/22)
A direct acyl radical addition to 2H-indazoles has been achieved for the first time, where the less-aromatic quinonoid 2H-indazoles readily accepted radical species to the C-3 position. Motivated by the lack of direct acylation strategy for 2H-indazoles, the current method utilizes the radical acceptability of 2H-indazoles, discovering an ambient temperature reaction to provide facile access to a diverse array of 3-acyl-2H-indazoles with three points of structural diversification in 25%-83% yields.