6275-26-9

Basic information

• Product Name: bis(4-methoxyphenyl)acetonitrile
• CAS NO: 6275-26-9
• Molecular Formula: C₁₆H₁₅NO₂
• Molecular Weight: 253.2958
• Mol File: 6275-26-9.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 400.7°C at 760 mmHg
• Flash Point: 143.5°C
• Density: 1.113g/cm³
• Vapor Pressure: 1.25E-06mmHg at 25°C
• Refractive Index: 1.559
• CAS DataBase Reference: bis(4-methoxyphenyl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: bis(4-methoxyphenyl)acetonitrile(6275-26-9)
• EPA Substance Registry System: bis(4-methoxyphenyl)acetonitrile(6275-26-9)

Safety Data

• Hazardous Substances Data: 6275-26-9(Hazardous Substances Data)

Upstream product

• 110-86-1 pyridine 
• 7142-92-9 tetrakis-(4-methoxy-phenyl)-succinonitrile 
• 100-63-0 phenylhydrazine 
• 62383-83-9 α-cyano-α-(methylthio)methyl chloride 
• 100-66-3 methoxybenzene 
• 33646-40-1 4-methoxymandelonitrile 
• 7664-93-9 sulfuric acid 
• 119072-55-8 tert-butylisonitrile 
• 7525-23-7 4,4'-dimethoxydiphenylmethyl chloride 
• 5720-07-0 4-methoxyphenylboronic acid 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 104-47-2 p-methoxybenzylnitrile 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 728-87-0 4,4'-Dimethoxybenzhydrol 

Downstream Products

• 115-42-4 4,4-bis-(4-methoxy-phenyl)-hexan-3-one 
• 7142-92-9 tetrakis-(4-methoxy-phenyl)-succinonitrile 
• 49740-19-4 4,4-[bis(p-methoxy-phenyl)]-4-cyano-2-methyl-butyric acid methyl ester 
• 1384881-77-9 C₁₉H₁₉NO₂ 

Relevant articles and documents

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A Diarylacetonitrile as a Molecular Probe for the Detection of Polymeric Mechanoradicals in the Bulk State through a Radical Chain-Transfer Mechanism

Since the beginning of polymer science, understanding the influence of mechanical stress on polymer chains has been a fundamental and important research topic. The detection of mechanoradicals generated by homolytic cleavage of the polymer chains in solut

Structure-based virtual screening, synthesis and biological evaluation of potential FAK-FAT domain inhibitors for treatment of metastatic cancer

Focal adhesion kinase (FAK) is a tyrosine kinase that is overexpressed and activated in several advanced-stage solid cancers. In cancer cells, FAK promotes the progression and metastasis of tumours. In this study, we used structure-based virtual screening to filter a library of more than 210K compounds against the focal adhesion targeting FAK-focal adhesion targeting (FAT) domain to identify 25 virtual hit compounds which were screened in the invasive breast cancer line (MDA-MB-231). Most notably, compound I showed low micromolar antiproliferative activity, as well as antimigratory activity. Moreover, examination in a model of triple negative breast cancer (TNBC), revealed that, despite not effecting FAK phosphorylation, compound I significantly impairs proliferation whilst impairing focal adhesion growth and turnover leading to reduced migration. Further optimisation and synthesis of analogues of the lead compound I using a four-step synthetic procedure was performed, and analogues were assessed for their antiproliferative activity against three breast cancer (MDA-MB-231, T47D, BT474) cell lines and one pancreatic cancer (MIAPaCa2) cell line. Compound 5f was identified as a promising lead compound with IC50 values in the range of 4.59–5.28 μM in MDA-MB-231, T47D, BT474, and MIAPaCa2. Molecular modelling and pharmacokinetic studies provided more insight into the therapeutic features of this new series.

Switchable Stereoselectivity in Bromoaminocyclization of Olefins: Using Br?nsted Acids of Anionic Chiral Cobalt(III) Complexes

Br?nsted acids of anionic chiral CoIII complexes act as bifunctional phase-transfer catalysts to shuttle the substrates across the solvent interface and control stereoselectivity. The diastereomeric chiral CoIII-templated Br?nsted ac