628-20-6 Usage
Description
4-Chlorobutyronitrile, with the CAS number 628-20-6, is a clear, colorless liquid used in organic synthesis. It has a flash point of 85°F and a density of approximately 9.7 lb/gal. 4-Chlorobutyronitrile is practically insoluble in water, with a solubility of only 2 parts per 100 parts of water, causing it to sink when mixed with water. Its vapors are heavier than air, and it can irritate the eyes but not the skin. When heated or involved in a fire, it releases hazardous gases such as hydrogen chloride, hydrogen cyanide, and hydrogen bromide.
Uses
Used in Organic Synthesis:
4-Chlorobutyronitrile is used as a synthetic building block in the chemical industry for the production of various organic compounds. Its unique chemical structure allows it to be a versatile reagent in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Chlorobutyronitrile is used as an intermediate in the synthesis of various drugs. Its ability to react with other compounds makes it a valuable component in the development of new medications with specific therapeutic properties.
Used in Agrochemical Industry:
4-Chlorobutyronitrile is also utilized in the agrochemical industry for the synthesis of pesticides and other crop protection agents. Its role in creating effective and targeted compounds contributes to the development of safer and more efficient products for agricultural use.
Used in Specialty Chemicals:
In the specialty chemicals sector, 4-Chlorobutyronitrile is employed as a key component in the production of various chemicals with specific applications. These can include materials for coatings, adhesives, and other industrial applications where unique properties are required.
Air & Water Reactions
Highly flammable. Practically insoluble in water.
Reactivity Profile
4-Chlorobutyronitrile may attack some forms of plastics [USCG, 1999].
Health Hazard
Chemical is moderately toxic. Inhalation causes irritation of nose and throat. Ingestion causes irritation of mouth and stomach. Contact with eyes causes irritation. Can penetrate the skin on prolonged contact; only slightly irritating.
Fire Hazard
Special Hazards of Combustion Products: Toxic and irritating hydrogen cyanide, hydrogen bromide, and hydrogen chloride may form in fires.
Check Digit Verification of cas no
The CAS Registry Mumber 628-20-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,2 and 8 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 628-20:
(5*6)+(4*2)+(3*8)+(2*2)+(1*0)=66
66 % 10 = 6
So 628-20-6 is a valid CAS Registry Number.
InChI:InChI=1/C4H6ClN/c5-3-1-2-4-6/h1-3H2
628-20-6Relevant articles and documents
Photoinduced Remote Functionalisations by Iminyl Radical Promoted C?C and C?H Bond Cleavage Cascades
Dauncey, Elizabeth M.,Morcillo, Sara P.,Douglas, James J.,Sheikh, Nadeem S.,Leonori, Daniele
supporting information, p. 744 - 748 (2017/12/13)
A photoinduced cascade strategy leading to a variety of differentially functionalised nitriles and ketones has been developed. These reactions rely on the oxidative generation of iminyl radicals from simple oximes. Radical transposition by C(sp3)?(sp3) and C(sp3)?H bond cleavage gives access to distal carbon radicals that undergo SH2 functionalisations. These mild, visible-light-mediated procedures can be used for remote fluorination, chlorination, and azidation, and were applied to the modification of bioactive and structurally complex molecules.
Efficient One-Step Transformation of Carboxylic Acids to Nitriles with the Carbon Chain Shortened by One Carbon Atom
Smushkevich, Y. I.,Smushkevich, V. Y.,Usorov, M. I.
, p. 1727 - 1736 (2007/10/03)
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FUNCTIONAL GROUP-TOLERANT HYDROALKYLATION OF ELECTRON-DEFICIENT OLEFINS THROUGH COPPER(I)-CATALYZED PHOTOADDITION OF ORGANIC HALIDES FOLLOWED BY REDUCTION WITH ZINC
Mitani, Michiharu,Hirayama, Hiroyuki
, p. 1562 - 1572 (2007/10/02)
A method of accomplishing hydroalkylation of electron-deficient olefins which tolerates a variety of functional groups, in which organic halides and electron-deficient olefins are subjected to a photoreaction catalyzed by the CuBr-Bun3P complex followed by treatment with Zn dust in the presence of AcOH, has been developed.