6280-31-5

Basic information

• Product Name: 1-BUTYL-1H-TETRAZOL-5-AMINE
• Synonyms: 1-BUTYL-1H-TETRAZOL-5-AMINE;1-BUTYL-1H-TETRAZOL-5-YLAMINE;CHEMBRDG-BB 4016426;AKOS LT-3X290;1-butyl-1H-tetrazol-5-amine(SALTDATA: FREE);1-Butyl-1H-tetrazol-5-amine AldrichCPR;1H-Tetrazol-5-amine,1-butyl-;1-butyltetrazol-5-amine
• CAS NO: 6280-31-5
• Molecular Formula: C₅H₁₁N₅
• Molecular Weight: 141.17
• Mol File: 6280-31-5.mol
• Article Data: 2

Chemical Properties

• Melting Point: 149-149.5 °C
• Boiling Point: 293.1 °C at 760 mmHg
• Flash Point: 131 °C
• Appearance: /
• Density: 1.34 g/cm³
• Vapor Pressure: 0.00176mmHg at 25°C
• Refractive Index: 1.639
• PKA: 2.04±0.10(Predicted)
• CAS DataBase Reference: 1-BUTYL-1H-TETRAZOL-5-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BUTYL-1H-TETRAZOL-5-AMINE(6280-31-5)
• EPA Substance Registry System: 1-BUTYL-1H-TETRAZOL-5-AMINE(6280-31-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 6280-31-5(Hazardous Substances Data)

Usage

Description

1-BUTYL-1H-TETRAZOL-5-AMINE is a versatile tetrazole derivative with the molecular formula C5H11N5, commonly utilized as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Its unique structure and properties lend it to a broad spectrum of applications across different industries.

Uses

Used in Pharmaceutical Industry:
1-BUTYL-1H-TETRAZOL-5-AMINE is used as a synthetic intermediate for the development of various pharmaceuticals, contributing to the creation of novel drugs and therapeutic agents.
Used in Agrochemical Industry:
1-BUTYL-1H-TETRAZOL-5-AMINE is used as a synthetic intermediate in the production of agrochemicals, aiding in the development of new pesticides and other agricultural chemicals to improve crop protection and yield.
Used in Explosive Materials:
1-BUTYL-1H-TETRAZOL-5-AMINE is used in the preparation of explosive materials, leveraging its properties to enhance the performance and safety of these products.
Used in Gas-Generating Systems:
1-BUTYL-1H-TETRAZOL-5-AMINE is utilized in gas-generating systems, where its reactivity and properties are harnessed to produce gases for various applications, such as inflating airbags or other safety devices.
Used in Cardiovascular Applications:
1-BUTYL-1H-TETRAZOL-5-AMINE has been studied for its potential use as a vasodilator, which could help in treating conditions related to blood vessel constriction and improving blood flow.
Used in Drug Delivery Systems:
1-BUTYL-1H-TETRAZOL-5-AMINE is considered as a component in drug delivery systems, where its properties may be employed to enhance the efficiency and targeting of therapeutic agents.

InChI:InChI=1/C5H11N5/c1-2-3-4-10-5(6)7-8-9-10/h2-4H2,1H3,(H2,6,7,9)

Upstream product

• 110-59-8 pentanonitrile 
• 506-68-3 bromocyane 
• 109-73-9 N-butylamine 
• 592-82-5 butyl isothiocyanate 
• 1516-32-1 N-butylthiourea 
• 13510-29-7 n-butylcyanamide 

Downstream Products

• 145181-89-1 [(1-Butyl-1H-tetrazol-5-ylamino)-(4-fluoro-phenyl)-methyl]-phosphonic acid dimethyl ester 
• 145181-94-8 (1-Butyl-1H-tetrazol-5-yl)-[1-(4-fluoro-phenyl)-meth-(E)-ylidene]-amine 

Relevant articles and documents

Iron-promoted sulfur sequestration for the substituent-dependent regioselective synthesis of tetrazoles and guanidines

We have established a facile and versatile synthetic methodology for the construction of tetrazoles and guanidines in the presence of an eco-friendly, inexpensive, easily available iron reagent. Aromatic thioureas with electron-donating substituents produced their respective target products in quantitative yield. In contrast, when electron-withdrawing substituted aromatic thioureas were used, the expected products were obtained in reduced yield. However, the desired products were obtained in good yield at moderate temperature. In addition, mechanistic studies revealed that the synthetic route involved iron-based subsequent reactions of addition and removal of sulfur.