6304-39-8

Basic information

• Product Name: Octanoic hydrazide
• Synonyms: CAPRYLIC HYDRAZIDE;CAPRYLOYL HYDRAZIDE;LABOTEST-BB LT00068484;OCTYL HYDRAZIDE;OCTANOIC ACID HYDRAZIDE;OCTANOIC HYDRAZIDE;octanohydrazide;octanoyl hydrazide
• CAS NO: 6304-39-8
• Molecular Formula: C₈H₁₈N₂O
• Molecular Weight: 158.24
• EINECS: 228-612-5
• Product Categories: Building Blocks;Carbonyl Compounds;Chemical Synthesis;Hydrazides;Organic Building Blocks
• Mol File: 6304-39-8.mol
• Article Data: 13

Chemical Properties

• Melting Point: 87-89 °C(lit.)
• Boiling Point: 301.8 °C at 760 mmHg
• Flash Point: 136.3 °C
• Appearance: White Flake Crystal
• Density: 0.929 g/cm³
• Vapor Pressure: 0.00103mmHg at 25°C
• Refractive Index: 1.456
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility: soluble in Methanol
• PKA: 13.62±0.18(Predicted)
• BRN: 1757322
• CAS DataBase Reference: Octanoic hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Octanoic hydrazide(6304-39-8)
• EPA Substance Registry System: Octanoic hydrazide(6304-39-8)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 6304-39-8(Hazardous Substances Data)

Usage

General Description

Octanoic hydrazide, also known as caproic hydrazide, is a chemical compound with the molecular formula C8H18N2O. It is a white crystalline solid that is commonly used as a food additive and flavoring agent due to its mild aroma. Octanoic hydrazide is also used in the production of various industrial products, such as plastics, pharmaceuticals, and agrochemicals. It is known for its ability to act as a corrosion inhibitor and is also used as a precursor in the synthesis of other organic compounds. Additionally, octanoic hydrazide has potential applications in the field of cosmetics and personal care products. While its specific mechanisms and properties are still being studied, octanoic hydrazide is considered to be relatively safe for use in approved applications.

InChI:InChI=1/C8H18N2O/c1-2-3-4-5-6-7-8(11)10-9/h2-7,9H2,1H3,(H,10,11)

Upstream product

• 111-11-5 methyl octanate 
• 124-07-2 Octanoic acid 
• 7151-55-5 N'-[benz-(E)-ylidene]octanehydrazide 
• 106-32-1 octanoic acid ethyl ester 

Downstream Products

• 111-64-8 n-octanoic acid chloride 
• 118808-21-2 4-Heptyloxy-benzoic acid N'-octanoyl-hydrazide 
• 118808-22-3 Octanoic acid 4-(N'-octanoyl-hydrazinocarbonyl)-phenyl ester 
• 5457-66-9 tert-butyl octanoate 
• 124-07-2 Octanoic acid 
• 111-11-5 methyl octanate 
• 589-75-3 butyl octanoate 
• 1551-42-4 octanoic acid cyclohexyl ester 
• 629-01-6 n-octanamide 
• 7151-55-5 N'-[benz-(E)-ylidene]octanehydrazide 
• 1074213-38-9 3-((2-octanoylhydrazono)methyl)-5-methylsalicylic acid 
• 1074213-33-4 C₂₄H₄₀N₂O₂ 

Relevant articles and documents

Microwave irradiated synthesis of Schiff bases of 4-(arylideneamino)-5-alkyl-2,4-dihydro-1,2,4-triazole-3-thione containing 1,2,4-triazole segment

Novel compounds based on the 1,2,4-triazole skeleton were synthesized. A class of 4-amino-5-alkyl-4H-1,2,4-triazole-3-thione created by reaction of thiocarbohydrazide with long-chain aliphatic carboxylic acids, and then the Schiff bases were obtained in the media of heat and microwave waves, in the presence and the absence of a catalyst. Their chemical structures were assayed by elemental analysis, also device spectroscopic methods.

Lipophilic gold(I) complexes with 1,3,4-oxadiazol-2-thione or 1,3-thiazolidine-2-thione moieties: synthesis and their cytotoxic and antimicrobial activities

Novel lipophilic gold(I) complexes containing 1,3,4-oxadiazol-2-thione or 1,3-thiazolidine-2-thione derivatives were synthesized and characterized by IR, high resolution mass spectrometry, and 1H, 13C 31P NMR. The cytotoxicity of the compounds was evaluated considering cisplatin and/or auranofin as reference in different tumor cell lines: colon cancer (CT26WT), metastatic skin melanoma (B16F10), breast adenocarcinoma (MCF-7), cervical carcinoma (HeLa), glioblastoma (M059?J). Normal human lung fibroblasts (GM07492-A) and kidney normal cell (BHK-21) were also evaluated. The gold(I) complexes were more active than their respective free ligands and cisplatin. Furthermore, antibacterial activity was evaluated against Gram-positive bacteria Staphylococcus aureus ATCC 25213, Staphylococcus epidermidis ATCC 12228 and Gram-negative bacteria Escherichia coli ATCC 11229 and Pseudomonas aeruginosa ATCC 27853 and expressed as the minimum inhibitory concentration (MIC). The complexes exhibited lower MIC values when compared to the ligands and chloramphenicol against Gram-positive bacteria and Gram-negative bacteria. Escherichia coli was sensitive one to the action of gold(I) complexes.

Development and assessment of green synthesis of hydrazides

An expeditious, solvent free one pot method for the preparation of hydrazides from corresponding acids directly under microwave irradiation is developed. The method has been assessed using green chemistry measures and found superior to conventional method with higher E(environmental) factor, atom economy, atom efficiency, carbon efficiency, reaction mass efficiency.