631-69-6 Usage
Description
BETA-BOSWELLIC ACID is a pentacyclic triterpene originally isolated from Boswellia that exhibits diverse bioactivities, including the inhibition of 5-lipoxygenase (5-LO) and cell proliferation in various cell types. It is characterized by its off-white solid appearance and has been found to have potential applications in the treatment of inflammation and other conditions.
Uses
Used in Pharmaceutical Industry:
BETA-BOSWELLIC ACID is used as an anti-inflammatory agent for its specific, nonredox inhibitory effect on 5-lipoxygenase, which is involved in the inflammatory process.
Used in Cancer Treatment:
BETA-BOSWELLIC ACID is used as a potential therapeutic agent for its ability to inhibit cell proliferation in various cancer cell lines, such as HL-60 cells, and its effects on nitric oxide and enzyme nitric oxide synthase (eNOS) in human umbilical vein endothelial cells (HUVECs).
Used in Platelet Aggregation:
BETA-BOSWELLIC ACID is used as a compound that increases calcium mobilization in platelets at concentrations ≥3 μM and induces platelet aggregation (EC50 = 8 μM), which may have implications for its use in the treatment of blood clotting disorders or related conditions.
Anticancer Research
It is a natural pentacyclic triterpenediol and occurs in Boswellia serrata plants as anisomeric blend of 3α, 24-dihydroxyolean-12-ene and 3α, 24-dihydroxyurs-12-ene.It induces apoptosis in various cancer cells. The events involved in this process areexcessive reactive oxygen species (ROS), nitric oxide (NO) formation, DNA ladderformation, and increased sub-G0 phase in cell cycle. This ultimately results incleavage of Bcl-2 and translocation of Bax to mitochondria, which lead to the lossof mitochondrial potential and release of cyt-c and other factors into cytosol. All these events are linked with reduced expression of survivin and inhibitor of caspase-activatedDNases (ICAD) that leads to the activation of poly(ADP-ribose) polymerase(PARP). The triterpene upregulates the expression of cell death receptor-4(DR-4) and tumor necrosis factor receptor-1 (TNF-R1), where both lead to activationof caspase-8 (Huang et al. 2000; Desai et al. 2008; Lu et al. 2008).
Check Digit Verification of cas no
The CAS Registry Mumber 631-69-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,3 and 1 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 631-69:
(5*6)+(4*3)+(3*1)+(2*6)+(1*9)=66
66 % 10 = 6
So 631-69-6 is a valid CAS Registry Number.
InChI:InChI=1/C30H48O3/c1-18-10-13-26(3)16-17-28(5)20(24(26)19(18)2)8-9-21-27(4)14-12-23(31)30(7,25(32)33)22(27)11-15-29(21,28)6/h8,18-19,21-24,31H,9-17H2,1-7H3,(H,32,33)/t18-,19+,21-,22-,23-,24+,26-,27-,28-,29-,30-/m1/s1
631-69-6Relevant articles and documents
Synthesis of new boswellic acid derivatives as potential antiproliferative agents
Shamraiz, Umair,Hussain, Hidayat,Ur Rehman, Najeeb,Al-Shidhani, Sulaiman,Saeed, Aasim,Khan, Husain Yar,Khan, Ajmal,Fischer, Lucie,Csuk, René,Badshah, Amin,Al-Rawahi, Ahmed,Hussain, Javid,Al-Harrasi, Ahmed
, p. 1845 - 1852 (2019/02/05)
In the current investigation, a series of heterocyclic derivatives of boswellic acids were prepared along with new monomers of 3-O-acetyl-11-keto-β-boswellic acid (AKBA, 1) 11-keto-β-boswellic acid (KBA, 2) and several new bis-AKBA and KBA homodimers and AKBA-KBA heterodimers. The effects of these compounds on the proliferation of different human cancer cell lines, viz., FaDu (pharynx carcinoma), A2780 (ovarian carcinoma), HT29 (colon adenocarcinoma), and A375 (malignant melanoma), have been evaluated. Thus, KBA homodimer 21 effectively inhibited the growth of FaDu, A2780, HT29, and A375 cells with EC50 values below 9 μM. In addition, compounds 7, 8, 11, 12, 15, 16, and 17 also exhibited cytotoxic effects for A2780, HT29, and A375 cancer cells. In particular, the pyrazine analog 8 was highly cytotoxic for A375 cancer cells with an EC50 value of 2.1 μM.
