632-46-2Relevant articles and documents
Treffers,Hammett
, p. 1708,1709 (1937)
CO2 (De)Activation in Carboxylation Reactions: A Case Study Using Grignard Reagents and Nucleophilic Bases
Valera Lauridsen, Jerik Mathew,Cho, Sung Yeon,Bae, Han Yong,Lee, Ji-Woong
supporting information, p. 1652 - 1657 (2020/03/30)
Carbon dioxide (CO2) is an intrinsically stable molecule. However, its reactivity toward nucleophilic bases has constituted an appealing characteristic for applications such as CO2 capture and functionalization. To shed light on the role of nucleophilic bases in CO2 functionalization, we performed some mechanistic studies using nitrogen-containing bases as an additive-in catalytic amounts-for carboxylation reactions of Grignard reagents. Our kinetic analysis and in situ infrared spectroscopy revealed the role of nucleophilic bases, particularly that of DBU (1,8-diazabicycloundec-7-ene), in CO2 (de)activation for carboxylation reactions.
Method for copper-catalyzed carboxylation reaction of arylboronic acid and carbon dioxide
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Paragraph 0087; 0088, (2019/12/29)
The invention discloses a method for a copper-catalyzed carboxylation reaction of arylboronic acid and carbon dioxide. According to the method, carbon dioxide is used as a C1 source, copper catalysisis adopted, alkoxide serves as alkali, and a reaction is carried out in an organic solvent; the method is simple in process and easy to implement, and shows wide functional group compatibility; the method allows various arylboronic acids such as monosubstituted or polysubstituted phenylboronic acid, polycyclic aromatic hydrocarbon boronic acid and benzoheterocyclic boronic acid to be converted into corresponding arylcarboxylic acids with considerable yield under mild conditions; and the produced carboxylic acids have important application value, and can be used for deriving a great number of other common chemical substances, such as acyl halide, acid anhydride, ester and amide.