63521-15-3

Basic information

• Product Name: Cefazedone sodium salt
• Synonyms: sodium (6R-trans)-7-[[(3,5-dichloro-4-oxo-1(4H)-pyridyl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;Cefazedone, sodium salt;Sodium (6R,7R)-7-[[(3,5-dichloro-4-oxo-1(4H)-pyridyl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;(6R,7R)-7-[[2-(3,5-Dichloro-4-oxopyridin-1(4H)-yl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(3,5-dichloro-4-oxo-1(4H)-pyridinyl)acetyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-, monosodium salt, (6R-trans)-;Nsc304118;Refosporin sodium salt
• CAS NO: 63521-15-3
• Molecular Formula: C₁₈H₁₄Cl₂N₅O₅S₃*Na
• Molecular Weight: 570.42503
• EINECS: 264-293-9
• Mol File: 63521-15-3.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Density: 1.78g/cm3
• Refractive Index: 1.76
• CAS DataBase Reference: Cefazedone sodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: Cefazedone sodium salt(63521-15-3)
• EPA Substance Registry System: Cefazedone sodium salt(63521-15-3)

Safety Data

• Hazardous Substances Data: 63521-15-3(Hazardous Substances Data)

Usage

Therapeutic Function

Antibiotic

InChI:InChI=1/C18H15Cl2N5O5S3/c1-7-22-23-18(33-7)32-6-8-5-31-16-12(15(28)25(16)13(8)17(29)30)21-11(26)4-24-2-9(19)14(27)10(20)3-24/h2-3,12,16H,4-6H2,1H3,(H,21,26)(H,29,30)

Upstream product

• 957-68-6 7-Aminocephalosporanic acid 
• 56187-47-4 cefazedone 
• 30246-33-4 (6R,7R)-7-amino-3-(5-methyl-1,3,4-thiadiazol-2-ylthiomethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 70149-51-8 3,5-Dichlor-4-pyridon-1-yl-ethylacetat 
• 107447-96-1 7-phenylacetylamino-3-(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid p-methoxybenzyl ester 
• 63760-59-8 7-aminocephalosporanic acid 

Relevant articles and documents

Synthesis process of cefazedone sodium

The invention relates to a synthesis process of cefazedone sodium, which is characterized in that a thioester compound synthesized by taking 3,5-dichloro-4-pyridone-1-acetic acid and 2-sulfydryl-5-methyl-1,3,4-thiadiazole as raw materials is directly subjected to a one-step reaction with 7-ACA to prepare the cefazedone sodium. The process has the advantages of simplified operation steps, mild production conditions, reduced generation of byproducts, simple production process, improved product yield and purity, reduced cost, small environmental pollution and better environmental friendliness, and enables the process to meet the requirements of industrialization.

New crystal form of cefazedone sodium salt and preparation method of new crystal form

The invention relates to a new crystal form of cefazedone sodium salt and a preparation method of the new crystal form, in particular to a crystal form of cefazedone sodium salt. The X-ray powder diffraction pattern of the crystal form of cefazedone sodium salt has characteristic diffraction peaks at the following 2theta angles: 5.108+/-0.2 degrees, 10.244+/-0.2 degrees, 12.355+/-0.2 degrees, 13.383+/-0.2 degrees, 16.124+/-0.2 degrees, 19.180+/-0.2 degrees, 20.740+/-0.2 degrees and 23.012+/-0 .2 degrees.

A head west spore alkone sodium synthetic method (by machine translation)

The invention belongs to the field of medical technology, discloses a head-west spore alkone sodium synthetic method. In order to 3, 5 - dichloro pyridone acetic acid and two sulfur thioalcohol thiazole as raw material synthetic active ester, with the 7 - amino cephalosporanic acid and mercapto tetrazole generated intermediate reaction, into west spore alkone sodium salt obtained by the head. The invention in 3 - substituted using mixed in the solvent, the reaction is more stable and smooth, reducing the generation of by-products, in the acylation reaction using the active ester, active high, conducive to the 7 - position of the acylation reaction, the resulting west spore alkone sodium yield and purity are relatively high. (by machine translation)