63659-59-6

Basic information

• Product Name: 2-(4-methoxyphenyl)ethyl mercaptan
• Synonyms: 2-(4-methoxyphenyl)ethyl mercaptan
• CAS NO: 63659-59-6
• Molecular Weight: 168.26
• Mol File: 63659-59-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-(4-methoxyphenyl)ethyl mercaptan(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)ethyl mercaptan(63659-59-6)
• EPA Substance Registry System: 2-(4-methoxyphenyl)ethyl mercaptan(63659-59-6)

Safety Data

• Hazardous Substances Data: 63659-59-6(Hazardous Substances Data)

Usage

General Description

2-(4-methoxyphenyl)ethyl mercaptan, also known as 4-Methoxyphenethyl mercaptan, is a chemical compound commonly used in the fragrance industry. It is a clear, pale yellow liquid with a strong, unpleasant odor. 2-(4-methoxyphenyl)ethyl mercaptan is often used as a base note in perfumes and fragrances due to its pungent and earthy scent. It is also used as a flavoring agent in the food industry, particularly in meat and savory products. Additionally, 2-(4-methoxyphenyl)ethyl mercaptan has been studied for its potential medicinal properties, including its antioxidant and anti-inflammatory effects. However, it should be handled with caution as it is corrosive and can cause irritation to the skin and eyes.

Upstream product

• 18217-00-0 1-(2-Chloroethyl)-4-methoxybenzene 
• 702-23-8 2-(4-Methoxyphenyl)ethanol 
• 104-01-8 4-Methoxyphenylacetic acid 
• 14425-64-0 4-methoxyphenethyl bromide 
• 17356-08-0 thiourea 

Downstream Products

• 57534-00-6 3-(4-methoxy-phenethylsulfanyl)-rifamycin 
• 63659-60-9 4-(2-cyclobutylmethylthio-ethyl)-1-methoxy-benzene 
• 1214263-72-5 (4'-methoxyphenyl)ethyl 2,3,4,6-tetra-O-acetyl-1-thio-β-D-glucopyranoside 
• 1448552-69-9 C₁₅H₁₃N₃O₄S 
• 1415676-41-3 C₁₇H₂₀N₄O₃S 
• 57534-02-8 C₄₆H₅₅NO₁₃S 
• 63659-65-4 1-[4-(2-cyclobutylmethylsulphonyl-ethyl)phenoxy]-2,3-epoxy propane 
• 63659-62-1 1-[4-(2-Cyclobutylmethylthio-ethyl)-phenoxy]-3-isopropylamino-propan-2-ol 
• 63686-83-9 1-[4-(2-cyclobutylmethylthio-ethyl)-phenoxy]-2,3-epoxy-propane 
• 63659-61-0 4-(2-Cyclobutylmethylthio-ethyl)-phenol 
• 63659-66-5 1-[4-(2-Cyclobutylmethylsulphonyl-ethyl)phenoxy]-3-isopropylamino-propan-2-ol 
• 63659-63-2 4-<<(cyclobutylmethyl)sulfonyl>ethyl>-1-methoxybenzene 
• 63659-64-3 4-<<(cyclobutylmethyl)sulfonyl>ethyl>phenol 
• 132004-90-1 (Z)-3-[2-(4-Methoxy-phenyl)-ethylsulfanyl]-but-2-enoic acid methyl ester 

Relevant articles and documents

Synthesis of Deuterated (E)-Alkene through Xanthate-Mediated Hydrogen-Deuterium Exchange Reactions

Herein we have developed a reversible hydrogen-deuterium exchange reaction of nonactivated olefins. By using EtOCS2K as a mediator, the H/D exchange reaction was realized through repeated addition and elimination reactions, demonstrating reversible H/D exchange between ordinary olefins and deuterated olefins. Using the lowest cost D2O without precious metal catalysts and ligands, a broad spectrum of compatibility of functional groups was achieved.

Inhibition of monoamine oxidase by 8-[(phenylethyl)sulfanyl]caffeine analogues

In a previous study we have investigated the monoamine oxidase (MAO) inhibitory properties of a series of 8-sulfanylcaffeine analogues. Among the compounds studied, 8-[(phenylethyl)sulfanyl]caffeine (IC50 = 0.223 μM) was found to be a particularly potent inhibitor of the type B MAO isoform. In an attempt to discover potent MAO inhibitors and to further examine the structure-activity relationships (SAR) of MAO inhibition by 8-sulfanylcaffeine analogues, in the present study a series of 8-[(phenylethyl)sulfanyl]caffeine analogues were synthesized and evaluated as inhibitors of human MAO-A and -B. The results document that substitution on C3 and C4 of the phenyl ring with alkyl groups and halogens yields 8-[(phenylethyl)sulfanyl]caffeine analogues which are potent and selective MAO-B inhibitors with IC50 values ranging from 0.017 to 0.125 μM. The MAO inhibitory properties of a series of 8-sulfinylcaffeine analogues were also examined. The results show that, compared to the corresponding 8-sulfanylcaffeine analogues, the 8-sulfinylcaffeins are weaker MAO-B inhibitors. Both the 8-sulfanylcaffeine and 8-sulfinylcaffeine analogues were found to be weak MAO-A inhibitors. This study also reports the MAO inhibition properties of selected 8-[(phenylpropyl)sulfanyl]caffeine analogues.

SYNTHESIS OF 1,2,3,4,5,6-HEXAHYDRO-8-HYDROXY-2,6-EPITHIO-3-BENZAZOCINE

In anticipation of diminishing narcotism of 1,2,3,4,5,6-hexahydro-8-hydroxy-2,6-methano-3-benzazocine opioids, the corresponding 2,6-epithio-3-benzazocines (2) have been synthesized by intramolecular cyclization of 1-(2-aminoethyl)-3,4-dihydro-1H-2-benzothiopyrans (9) with tert-butyl hypochlorite, and subsequent treatment of the 5-membered cyclic aminosulfonium salts (17) with NaOH.