641-70-3 Usage
Description
3-Nitrophthalic anhydride is an organic compound that serves as an important intermediate in the synthesis of various pharmaceuticals and chemical compounds. It is characterized by the presence of a nitro group and an anhydride functional group, which contribute to its reactivity and versatility in chemical reactions.
Uses
Used in Pharmaceutical Industry:
3-Nitrophthalic anhydride is used as a key intermediate in the synthesis of a benzimidazole PARP inhibitor I (succinate salt), known as ABT-472. 3-Nitrophthalic anhydride has potential applications in the development of drugs targeting cancer treatment by inhibiting the activity of PARP enzymes, which play a crucial role in DNA repair mechanisms.
Used in Organic Synthesis:
3-Nitrophthalic anhydride is utilized as a reactive intermediate in the synthesis of various organic compounds, including phthalimidoquinazolinones. These compounds can be obtained through reactions with aminoquinazolinones, showcasing the versatility of 3-nitrophthalic anhydride in organic synthesis and its potential applications in the development of new chemical entities with diverse properties and functions.
Preparation
3-Nitrophthalic anhydride can be prepared by heating 3-nitrophthalic acid under various conditions and by the action of acetic anhydride, essentially as in the procedure described. The direct nitration of phthalic anhydride yields 3-nitrophthalic anhydride together with the isomeric 4-nitro compound.
Purification Methods
Crystallise it from *C6H6, *C6H6/pet ether, Me2CO, AcOH, or Ac2O (m 164-165o). Dry it at 100o. [Beilstein 17 III/IV 6149, 17/11 V 266.]
Check Digit Verification of cas no
The CAS Registry Mumber 641-70-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,4 and 1 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 641-70:
(5*6)+(4*4)+(3*1)+(2*7)+(1*0)=63
63 % 10 = 3
So 641-70-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H3NO5/c10-7-4-2-1-3-5(9(12)13)6(4)8(11)14-7/h1-3H
641-70-3Relevant articles and documents
Solvent-free synthesis of new chalcone derivatives from 3-nitro phthalic acid and evaluation of their biological activities
Ahamed, Luma S.,Ali, Rana Abid,Ahmed, Rana S.
, p. 2963 - 2968 (2021/05/28)
Synthesis of 2-(4-Acetyl-phenyl)-4-nitro-isoindole-1, 3-dione chalcones were performed by fusion of 3-nitro phthalic anhydride with p-aminoacetophenone. Then the later was grinded with different aromatic aldehydes in the presence of sodium hydroxide to produce new chalcones derivatives A3-10 without using any solvent formation of new Narylphthailimide chalcones were confirmed by FT-IR,1HNMR, 13CNMR spectroscopy and all final compounds were tested for their antifungal and antibacterial activity some of them showed more biological activity than the standard drugs.
ANTIVIRAL 1,3-DI-OXO-INDENE COMPOUNDS
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Paragraph 0264, (2021/10/22)
The invention provides compounds of Formula (I): as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections.
Preparation method of 3-nitrophthalic anhydride
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Paragraph 0013-0015, (2019/04/10)
The invention relates to a preparation method of 3-nitrophthalic anhydride. The method includes the following steps: placing 3-nitrophthalic acid in a reaction solvent, adding a catalyst, and heatingfor reaction; and removing the reaction solvent and the catalyst from an obtained substance under negative pressure to obtain the 3-nitrophthalic anhydride. In the preparation method, the 3-nitrophthalic acid raw material can be easily obtained, the 3-nitrophthalic anhydride is synthesized by direct catalytic dehydration in one step, and the preparation method has the advantages of simple process,low cost, high yield and no by-products.