64357-46-6

Basic information

• Product Name: (4-ethylphenyl)(4-methylphenyl)methanone
• CAS NO: 64357-46-6
• Molecular Formula: C₁₆H₁₆O
• Molecular Weight: 224.2976
• Mol File: 64357-46-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 362.7°C at 760 mmHg
• Flash Point: 156.9°C
• Density: 1.035g/cm³
• Vapor Pressure: 1.9E-05mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: (4-ethylphenyl)(4-methylphenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (4-ethylphenyl)(4-methylphenyl)methanone(64357-46-6)
• EPA Substance Registry System: (4-ethylphenyl)(4-methylphenyl)methanone(64357-46-6)

Safety Data

• Hazardous Substances Data: 64357-46-6(Hazardous Substances Data)

Usage

Description

(4-ethylphenyl)(4-methylphenyl)methanone, also known as ethcathinone, is a synthetic stimulant belonging to the cathinone class of drugs. It is structurally related to cathinone, a natural amphetamine-like compound found in the khat plant. Ethcathinone has stimulant effects on the central nervous system, resulting in increased alertness, euphoria, and heightened physical activity.

Uses

Used in Recreational Drug Industry:
Ethcathinone is used as a recreational drug for its stimulant effects on the central nervous system, which include increased alertness, euphoria, and heightened physical activity. However, it has been associated with adverse effects such as increased heart rate, hypertension, and potential addiction.
Due to its abuse potential and potential for harm, ethcathinone has been classified as a controlled substance in many countries.

Upstream product

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Relevant articles and documents

Carbonylative Suzuki coupling reactions catalyzed by ONO pincer–type Pd(II) complexes using chloroform as a carbon monoxide surrogate

Benzoylhydrazone Schiff base–ligated three new ONO pincer–type palladium(II) complexes, [(PdL1(PPh3)] (1), [(PdL2(PPh3)] (2), and [(PdL3(PPh3)] (3), were synthesized by the reaction of the respective ligand, N-(2-hydroxybenzylidene)benzohydrazide (HL1), N-(2-hydroxy-3-methoxybenzylidene)benzohydrazide (HL2), or N-(5-bromo-2-hydroxybenzylidene) benzohydrazide (HL3), with Pd(OAc)2 and PPh3 in methanol and isolated as air-stable reddish-orange crystalline solids in high yields (78%–83%). All three complexes were fully characterized by elemental analysis, Fourier-transform infrared spectroscopy, UV–Visible, 1H nuclear magnetic resonance (NMR), 13C{1H} NMR, and 31P{1H} NMR spectroscopic studies. The molecular structure of all three complexes was established unambiguously by single-crystal X-ray diffraction studies which revealed a distorted square planar geometry of all three complexes. The ONO pincer–type ligands occupied three coordination sites at the palladium, while the fourth site is occupied by the monodentate triphenylphosphine ligand. The catalytic potential of all three complexes was explored in the carbonylative Suzuki coupling of aryl bromides and iodides with arylboronic acids to yield biaryl ketones, using CHCl3 as the source of carbonyl. The reported protocol is convenient and safe as it obviates the use of carbon monoxide (CO) balloons or pressured CO reactors which are otherwise needed for the carbonylation reactions. The methodology has been successfully applied to the synthesis of two antineoplastic drugs, namely, phenstatin and naphthylphenstatin, in good yields (81% and 85%, respectively). Under the optimized reaction conditions, complex 2 exhibited the best catalytic activity in the carbonylative Suzuki couplings. The reported catalysts have wide reaction scope with good functional group tolerance. All catalysts could be retrieved from the reaction after completion and recycled up to three times with insignificant loss in the catalytic activity.