65120-75-4Relevant articles and documents
Synthesis and antitumor activities of sinomenine derivatives on rings A and C
Wei, Can-Jing,Xu, Fang,Shi, Meng-Jiao,Hu, Jia-Wen,Wang, Jia-Jia,Zhen, Bo,Wang, Xue,Ji, Teng-Fei,Wang, Jin-Hua,Du, Guan-Hua
, p. 277 - 291 (2018)
A series of new sinomenine derivatives were designed, synthesized, and evaluated in tumor inhibitory activity, such as human triple negative breast cancer cell line (MDA-MB-231), glioma cell line (A172), human lung cancer cell line (A549), human colon cancer cell line (HCT-8). The modifications were carried out on rings A and C of the sinomenine by esterificating on phenolic hydroxyl with good yields. The highlight of this work was that the synthetic procedures were concise and sinomenine derivatives demonstrated promising antitumor activities.