65351-52-2

Basic information

• Product Name: O-methyl cyclohexylthiocarbamate
• CAS NO: 65351-52-2
• Molecular Formula: C₈H₁₅NOS
• Molecular Weight: 173.2758
• Mol File: 65351-52-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 227.8°C at 760 mmHg
• Flash Point: 91.6°C
• Density: 1.06g/cm³
• Vapor Pressure: 0.0759mmHg at 25°C
• Refractive Index: 1.522
• CAS DataBase Reference: O-methyl cyclohexylthiocarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: O-methyl cyclohexylthiocarbamate(65351-52-2)
• EPA Substance Registry System: O-methyl cyclohexylthiocarbamate(65351-52-2)

Safety Data

• Hazardous Substances Data: 65351-52-2(Hazardous Substances Data)

Upstream product

• 19708-81-7 methyl O-methyldithiocarbonate 
• 108-91-8 cyclohexylamine 
• 67-56-1 methanol 
• 931-53-3 Cyclohexyl isocyanide 

Downstream Products

• 51861-05-3 S-Methyl N-cyclohexyl(thiocarbamate) 
• 3173-53-3 Cyclohexyl isocyanate 

Relevant articles and documents

A novel three-component reaction between isocyanides, alcohols or thiols and elemental sulfur: A mild, catalyst-free approach towards O-thiocarbamates and dithiocarbamates

A new multicomponent reaction has been developed between isocyanides, sulfur and alcohols or thiols under mild reaction conditions to afford O-thiocarbamates and dithiocarbamates in moderate to good yields. The one-pot reaction cascade involves the formation of an isothiocyanate intermediate, thus a catalyst-free synthesis of isothiocyanates, as valuable building blocks from isocyanides and sulfur is proposed, as well. The synthetic procedure suits the demand of a modern organic chemist, as it tolerates a wide range of functional groups, it is atom economic and easily scalable.

Process to prepare alkyl-ureas from O,S-dimethyl dithiocarbonate

The present invention relates to the preparation of alkyl-ureas, starting from O,S-dimethyl dithiocarbonate, which provides the following steps: A) causing the O,S-dimethyl dithiocarbonate to react with a primary amine of general formula R1NH2in order to obtain an O-methyl thiocarbamate; B) isomerising the O-methyl thiocarbamate in order to obtain an S-methyl thiocarbamate; C) causing the S-methyl thiocarbamate with a compound of general formula R′R″NH, wherein R′ and R″ may be equal or different one in respect of the other and of R1and may be H, R2or R3, in order to obtain one of the alkyl-ureas of formula (4), (5) or (6).