657-27-2Relevant articles and documents
Chiral Receptors for Lysine Based on Covalently Linked Bis- and Tris-binaphthylphosphoric Acids
Octa-Smolin, Frescilia,Thiele, Maike,Yadav, Rohan,Platzek, André,Clever, Guido H.,Niemeyer, Jochen
supporting information, p. 6153 - 6156 (2018/10/05)
The synthesis and application of three chiral receptors based on the covalent linkage of 1,1′-binaphthylphosphoric acids is reported. The binding of the lysine enantiomers to the chiral receptors was investigated by DOSY-NMR and NMR titrations, revealing that the bisphosphoric acid 1d acts as a highly stereoselective receptor for binding of d-lysine.
Polyunsaturated fatty acid derivatives, pharmaceutical compositions containing the same, method for the preparation thereof, and their use as medicament
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, (2008/06/13)
The compounds of the Formula (I) STR1 wherein R1 is a C18-24 alkenyl containing at least two double bonds, or --(CH2)n --CH(NH2)m --COOH X is 0, NH or C1-4 alkyl-N, Y is CONH2, COOH or COOMe, wherein Me is hydrogen metal, and R2 is a side chain of a any amino acid except L-GLU or L-ASP at α-position or a group of Formula wherein k is zero or an integer of 1, n is zero or an integer of 1 to 3, m is zero or an integer of 1 to 4, A is hydroxyl or one A is hydroxyl and the other A is hydrogen. M is H or R1 --CO and X and R1 are as defined above and their salts having tyrosine kinase inhibitor activity can be used as antitumor agents.
Enantioselective synthesis of isotopically labelled α-amino acids. Preparation of (ε-13C)-L-α-aminoadipic acid and five isotopomers of L-lysine with 13C, 15N and 2H in the δ and ε-positions
Raap, J.,Wielen, C. M. van der,Lugtenburg, J.
, p. 277 - 286 (2007/10/02)
An asymmetric synthesis of the six-carbon α-amino acids (ε-13C)-L-α-aminoadipic acid and various isotopomers of L-lysine is described.The synthesis is based on a general method starting from the bis-lactim ether of cyclo(D-Val-Gly) and simple labelled reagents like K(13)CN, K(13)C15N, (13)CH3CN and LiAl(2)H4.Using this route (ε-13C)-L-α-aminoadipic acid was prepared in 31percent yield based on the labelled potassium cyanide.Five different isotopomers of L-lysine were prepared in high overall yield (45percent based on the labelled starting compound): (ε-13C)-L-lysine,(ε-13C,ε-15N)-L-lysine, (δ-13C)-L-lysine, (ε-2H2)-L-lysine and (ε-13C,ε-2H2)-L-lysine.The isotopomers were characterized using various spectroscopic techniques, e.g., 1H NMR, 2H NMR, 13C NMR, 15N NMR and mass spectrometry.The 31.2-ppm and the 27.6-ppm peak in the 13C NMR spectrum of lysine could be unambiguously assigned to the β- and δ-carbons, respectively.This means that the assignment previously reported is incorrect.
