65953-56-2

Basic information

• Product Name: N-Biotinyl-1,6-hexanediaMine
• Synonyms: N-Biotinyl-1,6-hexanediaMine;(3aS,4S,6aR)-N-(6-AMinohexyl)hexahydro-2-oxo- 1H-thieno[3,4-d]iMidazole-4-pentanaMide;[3aS-(3aα,4β,6aα)]-N-(6-AMinohexyl)hexahydro-2-oxo-1H-thieno[3,4-d]iMidazole-4-pentanaMide;N-(6-AMinohexyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]iMidazol-4-yl)pentanaMide;5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-(6-aminohexyl)pentanamide
• CAS NO: 65953-56-2
• Molecular Formula: C₁₆H₃₀N₄O₂S
• Molecular Weight: 342
• Product Categories: Amines;Biotin Derivatives;Chiral Reagents;Intermediates
• Mol File: 65953-56-2.mol
• Article Data: 10

Chemical Properties

• Melting Point: 184-186°C
• Boiling Point: 655.0±50.0 °C(Predicted)
• Appearance: /
• Density: 1.116±0.06 g/cm3(Predicted)
• Storage Temp.: -20?C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 13.90±0.40(Predicted)
• CAS DataBase Reference: N-Biotinyl-1,6-hexanediaMine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Biotinyl-1,6-hexanediaMine(65953-56-2)
• EPA Substance Registry System: N-Biotinyl-1,6-hexanediaMine(65953-56-2)

Safety Data

• Hazardous Substances Data: 65953-56-2(Hazardous Substances Data)

Usage

Description

N-Biotinyl-1,6-hexanediamine is a chemical compound that consists of a biotin molecule attached to a 1,6-hexanediamine chain. It is a versatile reagent used in various applications due to its unique structure and properties.

Uses

Used in Biochemistry Research:
N-Biotinyl-1,6-hexanediamine is used as an intermediate in the preparation of serum biotinidase resistant biotin derivatives. This allows for the development of pretargeted diagnosis of tumors, enabling more accurate and efficient detection of cancerous cells.
Used in Pharmaceutical Industry:
N-Biotinyl-1,6-hexanediamine is used as a building block for the synthesis of biotinylated compounds, which have potential applications in drug development. The biotinylation of drugs can improve their targeting, delivery, and therapeutic efficacy.
Used in Diagnostics:
N-Biotinyl-1,6-hexanediamine is used as a component in the development of diagnostic assays and kits. Its ability to bind to avidin or streptavidin with high affinity makes it a valuable tool for the detection and quantification of various biomolecules.
Used in Immunology:
N-Biotinyl-1,6-hexanediamine is used in the creation of immunoassays, where it can be attached to antibodies or other proteins to facilitate their detection and quantification. This is particularly useful in research and clinical settings for the study of immune responses and the development of diagnostic tests.
Overall, N-Biotinyl-1,6-hexanediamine is a valuable compound with a wide range of applications in various fields, including biochemistry research, pharmaceuticals, diagnostics, and immunology. Its unique properties and versatility make it an essential tool for the development of new technologies and therapies.

Upstream product

• 124-09-4 1,6-Hexanediamine 
• 33755-53-2 D-(+)-biotin 2-nitrophenyl ester 
• 35013-72-0 biotin N-Hydroxysuccinimide ester 
• 51644-96-3 5-tert-butoxycarbonylamino-1-aminopentane 
• 51857-17-1 tert-butyl N-(6-aminohexyl)carbamate 
• 58-85-5 biotin 
• 65915-94-8 N-(tert-butoxycarbonyl)-1,6-diaminohexane hydrochloride 
• 153162-70-0 tert-butyl (6-(5-((3aS,4S,6aR)-3a,6a-dimethyl-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexyl)carbamate 

Downstream Products

• 1069074-66-3 C₇₆H₉₆N₄O₁₄S 
• 1069074-68-5 C₁₃₀H₁₅₂N₄O₂₄S 
• 1069074-71-0 C₇₆H₉₆N₄O₁₄S 
• 1069074-73-2 C₁₃₀H₁₅₂N₄O₂₄S 
• 1383564-36-0 tert-butyl-6-(4-benzoylbenzamido)-1-oxo-1-(6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-pentanamido)hexylamino)hexan-2-ylcarbamate 
• 1383564-32-6 4-benzoyl-N-(6-oxo-6-(6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)-hexylamino)-5-(4-sulfamoylbenzamido)hexyl)benzamide 
• 1383564-33-7 4-benzoyl-N-(5-(4-methoxybenzamido)-6-oxo-6-(6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexylamino)hexyl)benzamide 
• 1276117-52-2 C₇₉H₁₀₄N₆O₁₈S 

Relevant articles and documents

Strategy and validation of a structure-based method for the discovery of selective inhibitors of PAK isoforms and the evaluation of their anti-cancer activity

p21 activated kinase 4 (PAK4), which belongs to the serine/threonine (Ser/Thr) protein kinase family, is a representative member of the PAK family and plays a significant role in multiple processes associated with cancer development. In this study, structure-based virtual screening was performed to discover novel and selective small molecule scaffolds, and a 6-hydroxy-2-mercapto-3-phenylpyrimidin-4(3H)-one-based compound (SPU-106, 14No.) was identified as an effective PAK4 inhibitor. By combining both a molecular docking study and molecular dynamics (MD) simulation strategies, the binding mode was determined in the PAK4 site. The SPU-106 compound could efficiently and selectively bind to the PAK4 kinase domain at an IC50 of 21.36 μM according to the kinase analysis. The designed molecular probe demonstrated that SPU-106 binds to the kinase domain in the C-terminus of PAK4. Further investigation revealed that the SPU-106 had a strong inhibitory effect on the invasion of SGC7901 cells but without any cytotoxicity. The western blot analysis indicated that the compound potently inhibited the PAK4/LIMK1/cofilin and PAK4/SCG10 signaling pathways. Thus, our work shows the successful application of computational strategies for the discovery of selective hits, and SPU-106 may be an effective PAK4 inhibitor for further development as an antitumor agent.

Biomolecule-compatible, highly branched polymer and biomolecular-recognition surface

A biomolecule-compatible highly branched polymer obtained by polymerizing a monomer having an alkylene oxide and two or more radically polymerizable double bonds in a molecule in presence of a polymerization initiator in 5 mol % or more and 200 mol % or less relative to the moles of monomer, wherein molecular terminals of biomolecule-compatible highly branched polymer have one biomolecular site of at least one pair from the group of combination pairs of biotin and avidin, an antigen and antibody, polynucleotide and polynucleotide having complementary base sequence thereof, cDNA and mRNA, enzyme and substrate, an enzyme and product, an enzyme and competitive inhibitor, an enzyme (binding site) and coenzyme, an enzyme (binding site) and triazine dye, protease and protease inhibitor, Fc site and protein A, Fc site and protein G, lectin and sugar, hormone receptor and hormone, DNA and DNA binding protein, heparin and fibronectin, and heparin and laminin.

Analyte detection utilizing polynucleotide sequences, composition, process and kit

A method of detecting in a sample an analyte (A) having a molecularly recognizable portion thereon, which comprises: providing (B) a molecular bridging entity having thereon: (i) a portion capable of recognizing the molecularly recognizable portion on the analyte; and (ii) a portion comprising a polynucleotide sequence; and (C) a signalling entity having thereon: (i) a polynucleotide portion capable of annealing to the polynucleotide portion of the bridging entity, thereby to form a stable polynucleotide hybrid, and (ii) a signal generating portion; forming a complex comprising: (1) the analyte (A) complexed through its molecularly recognizable portion to (2) the recognizing portion of the entity (B); the entity (B) being complexed through the polynucleotide portion thereon to (3) the polynucleotide portion of the signalling entity; and detecting a signal by means of the signal generating portion present in the complex.