66340-33-8

Basic information

• Product Name: 3-Desacetyl CefotaxiMe Lactone
• Synonyms: 3-Desacetyl CefotaxiMe Lactone;[5aR-[5aα,6β(Z)]]-2-AMino-α-(MethoxyiMino)-N-(1,4,5a,6-tetrahydro-1,7-dioxo-3H,7H-azeto[2,1-b]furo[3,4-d][1,3]thiazin-6-yl)-4-thiazoleacetaMide;3-Desacetyl CefotaxiMe Lactone (IMpurity E);Ceftriaxone IMpurity B;CefotaxiMe Related CoMpound E;Cefotaxime EP Impurity B;Ceftriaxone Sodium EP Impurity B(Cefotaxime EP Impurity E);Deacetylcefotaxime lactone ,Cefotaxime Impurity E (EP)
• CAS NO: 66340-33-8
• Molecular Formula: C₁₄H₁₃N₅O₅S₂
• Molecular Weight: 395.41352
• Product Categories: Impurity;Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 66340-33-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.99±0.1 g/cm3(Predicted)
• PKA: 8.25±0.20(Predicted)
• CAS DataBase Reference: 3-Desacetyl CefotaxiMe Lactone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Desacetyl CefotaxiMe Lactone(66340-33-8)
• EPA Substance Registry System: 3-Desacetyl CefotaxiMe Lactone(66340-33-8)

Safety Data

• Hazardous Substances Data: 66340-33-8(Hazardous Substances Data)

Usage

Description

3-Desacetyl CefotaxiMe Lactone is a chemical compound that is identified as an impurity in Cefotaxime sodium, a widely used antibiotic. It is also recognized as a degradation product for other cephalosporin antibiotics, including Ceftriaxone, Cefodizime, and Ceftiofur. 3-Desacetyl CefotaxiMe Lactone plays a significant role in the pharmaceutical industry, particularly in the context of antibiotic development and quality control.

Uses

Used in Pharmaceutical Industry:
3-Desacetyl CefotaxiMe Lactone is used as an impurity marker for [application reason] ensuring the quality and purity of Cefotaxime sodium and related cephalosporin antibiotics. Its identification and control are crucial in maintaining the safety and efficacy of these life-saving drugs.
Additionally, as a degradation product, 3-Desacetyl CefotaxiMe Lactone is used in the study of the stability and shelf life of cephalosporin antibiotics such as Ceftriaxone, Cefodizime, and Ceftiofur. Understanding the degradation pathways and the formation of this compound can help in the development of more stable and effective antibiotic formulations.
In Quality Control:
3-Desacetyl CefotaxiMe Lactone is used as a reference compound for [application reason] quality control testing in the manufacturing process of cephalosporin antibiotics. Its presence is monitored to ensure that the production process meets the required standards and that the final product is free from harmful impurities.
In Research and Development:
3-Desacetyl CefotaxiMe Lactone is utilized as a research compound for [application reason] investigating the mechanisms of antibiotic degradation and the factors that influence the stability of cephalosporin antibiotics. This knowledge can contribute to the improvement of drug formulations and the development of new, more stable antibiotics to combat bacterial resistance.

Upstream product

• 758680-79-4 cefotaxime 
• 86329-79-5 Kenicef 

Relevant articles and documents

Acidic degradation of cefodizime (THR-221) and structural elucidation of the products. I

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