66938-29-2

Basic information

• Product Name: 2-FLUORO-4'-METHOXYBENZOPHENONE
• Synonyms: 2-FLUORO-4'-METHOXYBENZOPHENONE;LABOTEST-BB LT00454689
• CAS NO: 66938-29-2
• Molecular Formula: C₁₄H₁₁FO₂
• Molecular Weight: 230.23
• EINECS: -0
• Product Categories: Aromatic Benzophenones & Derivatives (substituted)
• Mol File: 66938-29-2.mol
• Article Data: 13

Chemical Properties

• Melting Point: 55-57°C
• Boiling Point: 155-160°C 5mm
• Flash Point: 155-160°C/5mm
• Appearance: /
• Density: 1.176 g/cm³
• BRN: 2107951
• CAS DataBase Reference: 2-FLUORO-4'-METHOXYBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-4'-METHOXYBENZOPHENONE(66938-29-2)
• EPA Substance Registry System: 2-FLUORO-4'-METHOXYBENZOPHENONE(66938-29-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 66938-29-2(Hazardous Substances Data)

Usage

General Description

2-Fluoro-4'-methoxybenzophenone is a chemical compound with the molecular formula C14H11FO2. It is a member of the benzophenone family and is commonly used as a building block in the synthesis of pharmaceuticals and organic compounds. 2-FLUORO-4'-METHOXYBENZOPHENONE is characterized by its benzophenone core structure, which consists of two benzene rings connected by a ketone group. The presence of a fluorine atom at the 2 position and a methoxy group at the 4' position of one of the benzene rings gives this compound its unique chemical properties. It is often used as a photoinitiator in the manufacturing of various types of polymers and resins, and it has potential applications in the pharmaceutical industry due to its ability to modulate biological processes.

Upstream product

• 100-66-3 methoxybenzene 
• 445-29-4 o-fluoro-benzoic acid 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 393-52-2 2-Fluorobenzoyl chloride 
• 201230-82-2 carbon monoxide 
• 696-62-8 para-iodoanisole 
• 1993-03-9 o-fluorophenylboronic acid 
• 348-52-7 1-Fluoro-2-iodobenzene 
• 5720-07-0 4-methoxyphenylboronic acid 
• 100-09-4 4-methoxybenzoic acid 
• 67695-80-1 1,3-dioxoisoindolin-2-yl 4-methoxybenzoate 
• 1072-85-1 o-fluorobromobenzene 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 98-86-2 acetophenone 

Downstream Products

• 1451489-90-9 3-(4-methoxyphenyl)-1,2-dimethyl-2,3-dihydro-1H-indazole 
• 55271-06-2 3-(4-methoxyphenyl)-1H-indazole 
• 1220532-01-3 C₁₈H₁₅NO₄ 
• 138947-58-7 1-(2-fluorophenyl)-1-(4-methoxyphenyl)-2-propyn-1-ol 
• 66938-59-8 (4-amino-3-nitrophenyl)-(2-fluorophenyl)methanone 

Relevant articles and documents

Tetra- And Dinuclear Palladium Complexes Based on a Ligand of 2,8-Di-2-pyridinylanthyridine: Preparation, Characterization, and Catalytic Activity

Complexation of L [L = 5-phenyl-2,8-di-2-pyridinyl-anthyridine] with [Pd(CH3CN)4](BF4)2 and [Pd(CH3CN)3Cl](BF4) in a molar ratio of 1:2 rendered the corresponding dinuclear complexes [Pd2L (CH3CN)4](BF4)4 (1) and [Pd2L (CH3CN)2Cl2](BF4)2 (2), respectively. However, treatment of L with (COD)PdCl2 followed by anion exchange yielded a tetranuclear complex [Pd4L3Cl4](PF6)4(4a). Structures of these complexes are characterized by both spectroscopy and X-ray crystallography. Interconversion of these three complexes was studied via the manipulation of stoichiometric ratio of ligand to metal precursor. The catalytic activity of these complexes for carbonylative Suzuki-Miyaura cross-coupling was investigated. Complex 2 shows an excellent catalytic activity on the reaction of aryl iodide with arylboronic acid in the presence of atmospheric pressure of CO to give the corresponding benzophenones.

Method of utilizing continuous flow microreactor to synthesize benzophenone derivative

The invention belongs to the technical field of organic synthesis, and particularly relates to a method of utilizing a continuous flow microreactor to synthesize a benzophenone derivative. The methodincludes: using aryl Grignard reagent and acyl chloride as raw materials; at normal temperature, continuously synthesizing the benzophenone derivative in the microreactor; recycling a reaction solvent2-methyl tetrahydrofuran. Problems of environmental pollution and reaction operation safety caused by the fact that conventional Fridel-Crafts reaction is excessively dependent on reagents like aluminum trichloride, ferric trichloride and zinc dichloride are avoided, the defect that novel catalytic processes are expensive in catalytic reagent and harsh in operation condition is made up, and continuous synthesis of a medical intermediate ketoprofen nitrile is realized efficiently. The method has the advantages of high operation convenience, high reaction safety, high yield, high efficiency andreaction solvent reusability and is environment-friendly and efficient.

Elemental step thermodynamics of various analogues of indazolium alkaloids to obtaining hydride in acetonitrile

A series of analogues of indazolium alkaloids were designed and synthesized. The thermodynamic driving forces of the 6 elemental steps for the analogues of indazolium alkaloids to obtain hydride in acetonitrile were determined using an isothermal titration calorimeter (ITC) and electrochemical methods, respectively. The effects of molecular structure and substituents on the thermodynamic driving forces of the 6 steps were examined. Meanwhile, the oxidation mechanism of NADH coenzyme by indazolium alkaloids was examined using the chemical mimic method. The result shows that the oxidation of NADH coenzyme by indazolium alkaloids in vivo takes place by one-step concerted hydride transfer mechanism.