679005-37-9

Basic information

• Product Name: 3-[4-((2S)-2-hydroxymethylpyrrolidine-1-carbonyl)-2-methoxy-5-nitrophenoxy]propionic acid benzyl ester
• Synonyms: 3-[4-((2S)-2-hydroxymethylpyrrolidine-1-carbonyl)-2-methoxy-5-nitrophenoxy]propionic acid benzyl ester
• CAS NO: 679005-37-9
• Molecular Weight: 458.468
• Mol File: 679005-37-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-[4-((2S)-2-hydroxymethylpyrrolidine-1-carbonyl)-2-methoxy-5-nitrophenoxy]propionic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[4-((2S)-2-hydroxymethylpyrrolidine-1-carbonyl)-2-methoxy-5-nitrophenoxy]propionic acid benzyl ester(679005-37-9)
• EPA Substance Registry System: 3-[4-((2S)-2-hydroxymethylpyrrolidine-1-carbonyl)-2-methoxy-5-nitrophenoxy]propionic acid benzyl ester(679005-37-9)

Safety Data

• Hazardous Substances Data: 679005-37-9(Hazardous Substances Data)

Upstream product

• 23356-96-9 (S)-1-Pyrrolidin-2-yl-methanol 
• 100-51-6 benzyl alcohol 
• 100059-65-2 3-methoxy-4-(3'-hydroxypropyloxy)benzoic acid 
• 121-34-6 3-methoxy-4-hydroxybenzoic acid 
• 679005-36-8 4-(2-benzyloxycarbonylethoxy)-5-methoxy-2-nitrobenzoic acid 
• 219562-36-4 3-(4-carboxy-2-methoxy-5-nitrophenoxy)propanoic acid 

Downstream Products

• 679005-39-1 3-[5-tert-butoxycarbonylamino-4-((2S)-2-hydroxymethylpyrrolidine-1-carbonyl)-2-methoxyphenoxy]propionic acid benzyl ester 
• 679005-40-4 (11S,11aS)-8-(2-benzyloxycarbonylethoxy)-11-hydroxy-7-methoxy-5-oxo-2,3,11,11a-tetrahydro-1H,5H-pyrrolo[2,1-c][1,4]benzodiazepine-10-carboxylic acid tert-butyl ester 
• 679005-38-0 3-[5-amino-4-((2S)-2-hydroxymethylpyrrolidine-1-carbonyl)-2-methoxyphenoxy]propionic acid benzyl ester 

Relevant articles and documents

ALKYL 4- [4- (5-OXO-2, 3, 5, 11A-TETRAHYD0-5H-PYRR0L0 [2, 1-C] [1, 4] BENZODIAZEPINE-8-YLOXY) -BUTYRYLAMINO]-1H-PYRROLE-2-CARBOXYLATE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF A PROLIFERATIVE DISEASE

A compound of formula (I); or a salt or solvate thereof, wherein: the dotted line indicates the optional presence of a double bond between C2 and C3; R2 is selected from -H, -OH, =0, =CH2, -CN, -R, OR, halo, =CH-R, O-SO2-R, CO2R and COR; R7 is selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR', nitro, Me3Sn and halo, where R and R' are independently selected from optionally substituted C1-7 alkyl, C3-20 heterocyclyl and C5-20 aryl groups; R10 and R11 either together form a double bond, or are selected from H and YRY, where Y is selected from O, S and NH and RY is H or C1-7 alkyl or H and SOxM, where x is 2 or 3, and M is a monovalent pharmaceutically acceptable cation; each X is independently a heteroarylene group; n is from 1 to 6; and RE is C1-4 alkyl. The compound is useful for the treatment of proliferative diseases.

Synthesis and biological evaluation of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) C8 cyclic amine conjugates

We report examples of a series of novel pyrrolo[2,1-c][1,4]benzodiazepine (PBD) analogues 12-15 prepared from a common functionalized building block 11 that can be conveniently synthesized on a large scale and in optically pure form. Isoindoline analogue