70097-65-3

Basic information

• Product Name: 1-BENZYLOXY-4-TRIFLUOROMETHYL-BENZENE
• Synonyms: 1-BENZYLOXY-4-TRIFLUOROMETHYL-BENZENE;4-(BENZYLOXY)BENZOTRIFLUORIDE;1-Benzyloxy-4-(trifluoromethyl)benzene, Benzyl 4-(trifluoromethyl)phenyl ether;4-(Benzyloxy)benzotrifluoride 98%;4-(Benzyloxy)benzotrifluoride98%
• CAS NO: 70097-65-3
• Molecular Formula: C₁₄H₁₁F₃O
• Molecular Weight: 252.23
• Mol File: 70097-65-3.mol
• Article Data: 35

Chemical Properties

• Appearance: /Solid
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-BENZYLOXY-4-TRIFLUOROMETHYL-BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYLOXY-4-TRIFLUOROMETHYL-BENZENE(70097-65-3)
• EPA Substance Registry System: 1-BENZYLOXY-4-TRIFLUOROMETHYL-BENZENE(70097-65-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 70097-65-3(Hazardous Substances Data)

Usage

General Description

1-BENZYLOXY-4-TRIFLUOROMETHYL-BENZENE, also known as 1-(BENZYLOXY)-4-(TRIFLUOROMETHYL)BENZENE, is a chemical compound with the molecular formula C14H11F3O. It is a white crystalline solid that is commonly used in organic synthesis and as a building block in the production of pharmaceuticals, agrochemicals, and other specialty chemicals. 1-BENZYLOXY-4-TRIFLUOROMETHYL-BENZENE is also known for its unique aromatic and hydrophobic properties, making it useful in various industrial applications. It is important to handle this chemical with care, as it may cause irritation to the respiratory system, skin, and eyes, and can be harmful if ingested or inhaled.

Upstream product

• 402-45-9 4-hydroxybenzotrifluoride 
• 100-39-0 benzyl bromide 
• 19578-68-8 4-(4-benzyloxyphenyl) iodide 
• 887144-97-0 Togni's reagent 
• 146631-00-7 [4-(benzyloxy)phenyl]boronic acid 
• 2926-29-6 Langlois reagent 
• 75-45-6 Chlorodifluoromethane 
• 887144-94-7 Togni's reagent II 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 1885-46-7 trifluoromethanesulfonic acid difluoromethyl ether 
• 108-88-3 toluene 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 100-51-6 benzyl alcohol 
• 540-38-5 p-Iodophenol 

Downstream Products

• 612833-41-7 [2-(phenylmethoxy)-5-(trifluoromethyl)phenyl]-boronic acid 
• 402-45-9 4-hydroxybenzotrifluoride 
• 108-88-3 toluene 

Relevant articles and documents

Method for synthesizing aryl benzyl ether compound

The invention discloses a method for synthesizing aryl benzyl ether compounds, which comprises the following steps: by using an iron (III) complex containing 1, 3-di-tert-butyl imidazole cations and having a molecular formula of [(tBuNCH = CHNtBu) CH] [FeBr4] as a catalyst and di-tert-butyl peroxide as an oxidant, carrying out oxidative coupling reaction on phenolic compounds and toluene compounds to synthesize the corresponding aryl benzyl ether compounds. The method is the first example for preparing the aryl benzyl ether compound through the oxidative coupling reaction of the phenolic compound and the toluene compound, which is realized by an iron-based catalyst, and has the advantages of atom economy, environmental friendliness and good substrate applicability.

Rational Design and Development of Low-Price, Scalable, Shelf-Stable and Broadly Applicable Electrophilic Sulfonium Ylide-Based Trifluoromethylating Reagents

The development of two highly reactive electrophilic trifluoromethylating reagents (trifluoromethyl)(4-nitrophenyl)bis(carbomethoxy)methylide (1g) and (trifluoromethyl)(3-chlorophenyl)bis(carbomethoxy)methylide (1j) through structure-activity study was described. Under mild conditions, reagent 1g reacted with β-ketoesters and silyl enol ethers to give α-trifluoromethylated-β-ketoesters or α-trifluoromethylated ketones in high yields. In addition, reagent 1g could serve as a trifluoromethyl radical for a variety of trifluoromethylative transformations under visible light irradiation, including radical trifluoromethylation of electron-rich indoles and pyrroles and sodium aryl sulfinates as well as trifluoromethylative difunctionalization with styrene derivatives. On the other hand, as a complimentary, under reductive coupling conditions, reagent 1j reacted with a variety of (hetero)aryl iodides for the formation of trifluoromethylated (hetero)arenes.

Cross-Coupling Reactions of Aryl Halides with Primary and Secondary Aliphatic Alcohols Catalyzed by an O,N,N-Coordinated Nickel Complex

A synthesis of alkyl aryl ethers was achieved via the cross-coupling of aryl halides with primary and secondary aliphatic alcohols catalyzed by a bench-stable nickel complex supported by a monoanionic O,N,N-tridentate ligand. This nickel-catalyzed reaction proceeds smoothly in the absence of a phosphine ligand, affording alkyl aryl ethers in moderate to good yields. (Figure presented.).