7033-51-4

Basic information

• Product Name: 6-CHLORO-2-PHENYLBENZO[D][1,3]OXAZIN-4-ONE
• Synonyms: 6-CHLORO-2-PHENYL-4H-3,1-BENZOXAZIN-4-ONE;6-CHLORO-2-PHENYLBENZO[D][1,3]OXAZIN-4-ONE;6-chloro-2-phenyl-4H-benzo[d][1,3]oxazin-4-one
• CAS NO: 7033-51-4
• Molecular Formula: C₁₄H₈ClNO₂
• Molecular Weight: 257.675
• Mol File: 7033-51-4.mol
• Article Data: 27

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-CHLORO-2-PHENYLBENZO[D][1,3]OXAZIN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-2-PHENYLBENZO[D][1,3]OXAZIN-4-ONE(7033-51-4)
• EPA Substance Registry System: 6-CHLORO-2-PHENYLBENZO[D][1,3]OXAZIN-4-ONE(7033-51-4)

Safety Data

• Hazardous Substances Data: 7033-51-4(Hazardous Substances Data)

Usage

Description

6-CHLORO-2-PHENYLBENZO[D][1,3]OXAZIN-4-ONE is a heterocyclic chemical compound with the molecular formula C14H8ClNO2. It features a benzoxazine ring with a chlorine atom at the 6-position and a phenyl group at the 2-position, giving it unique structural properties that may contribute to its potential applications in organic synthesis and medicinal chemistry.

Uses

Used in Organic Synthesis:
6-CHLORO-2-PHENYLBENZO[D][1,3]OXAZIN-4-ONE is used as a building block in the synthesis of other organic compounds, leveraging its unique structure to create a variety of complex molecules for different applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 6-CHLORO-2-PHENYLBENZO[D][1,3]OXAZIN-4-ONE is used as a starting material for the development of pharmaceuticals. Its potential therapeutic applications are being explored, with the aim of discovering new drugs that can benefit from its chemical properties.
Further research and exploration of 6-CHLORO-2-PHENYLBENZO[D][1,3]OXAZIN-4-ONE's chemical and biological properties are necessary to fully understand and harness its potential uses and applications across various industries.

Upstream product

• 13421-00-6 5-chloro-2-iodo-benzoic acid 
• 100-47-0 benzonitrile 
• 63069-48-7 p-chloro-o-iodoaniline 
• 98-88-4 benzoyl chloride 
• 1864-94-4 phenyl formate 
• 495-18-1 Benzohydroxamic acid 
• 19226-36-9 3-phenyl-5H-1,4,2-dioxazol-5-one 
• 591-50-4 iodobenzene 
• 201230-82-2 carbon monoxide 
• 17630-76-1 5-chloroindole 2,3-dione 
• 611-73-4 Benzoylformic acid 
• 20028-53-9 2-amino-5-chlorobenzaldehyde 
• 147611-23-2 N-(4-chloro-2-formylphenyl)benzamide 
• 1042223-42-6 N-(4-chloro-2-(phenylethynyl)phenyl)-2,2,2-trifluoroacetamide 

Downstream Products

• 21259-25-6 N-Benzoyl-2-amino-5-chlorobenzophenone 
• 869365-84-4 N-[4-chloro-2-(2-methyl-benzoyl)-phenyl]-benzamide 
• 170301-12-9 4-chloro-2-(2'-thienylcarbonyl)-N-benzoylaniline 
• 170301-13-0 4-chloro-2-(2'-furoyl)-N-benzoylaniline 
• 41631-21-4 2-amino-5-chlorophenyl 2-thienyl ketone 
• 60514-58-1 (2-amino-5-chlorophenyl)(2-furyl)methanone 
• 91805-28-6 4-chloro-2-(2'-furoyl)-N-bromoacetylaniline 
• 39860-60-1 4-chloro-2-(2'-thienylcarbonyl)-N-bromoacetylaniline 
• 1256947-87-1 C₂₁H₁₅ClN₄O₂ 
• 1256947-92-8 C₂₁H₁₃ClN₄O 
• 7012-93-3 6-chloro-2,3-diphenylquinazolin-4(3H)-one 
• 1402939-28-9 6-chloro-3-(4-methylphenyl)-2-phenylquinazolin-4(3H)-one 

Relevant articles and documents

Direct synthesis of benzoxazinones via Cp*Co(III)-catalyzed C–H activation and annulation of sulfoxonium ylides with dioxazolones

A highly novel and direct synthesis of benzoxazinones was developed via Cp*Co(III)-catalyzed C–H activation and [3 + 3] annulation between sulfoxonium ylides and dioxazolones. The reaction is conducted under base-free conditions and tolerates various functional groups. Starting from diverse readily available sulfoxonium ylides and dioxazolones, a variety of benzoxazinones could be synthesized in one step in 32%-75% yields.

Recyclable Heterogeneous Palladium-Catalyzed Carbonylative Cyclization of 2-Iodoanilines with Aryl Iodides Leading to 2-Arylbenzoxazinones

A highly efficient and practical heterogeneous palladium-catalyzed carbonylative coupling of 2-iodoanilines with aryl iodides has been developed. The reaction occurs smoothly in toluene at 110 °C with N, N -diisopropylethylamine as base under carbon monoxide (5 bar) and offers a general and powerful tool for the construction of various valuable 2-arylbenzoxazinones with excellent atom-economy, high functional group tolerance, good to high yields, and easy recyclability of the palladium catalyst. The reaction is the first example of heterogeneous palladium-catalyzed carbonylative coupling for the preparation of diverse 2-arylbenzoxazinones from commercially easily available 2-iodoanilines and aryl iodides.

Palladium (0)-catalyzed C(sp2)-H oxygenation with carboxylic acids

Palladium (0)-catalyzed Ortho-benzoxylation of the sp2 C–H bond of arylbenzoxazinones with carboxylic acid is reported. With benzoxazinone as directing group, the reaction went smoothly under the benign condition and gave the desired product wi