72-40-2 Usage
Description
4-Amino-5-imidazolecarboxamide hydrochloride is an organic compound that serves as an essential intermediate in the synthesis of various heterocyclic compounds, including guanine, purines, and pyrimidines. These compounds play a crucial role in the formation of nucleic acids and are vital for various biological processes.
Uses
Used in Pharmaceutical Industry:
4-Amino-5-imidazolecarboxamide hydrochloride is used as a key intermediate in the synthesis of heterocyclic compounds for the development of pharmaceuticals. Its role in the formation of guanine, purines, and pyrimidines makes it an important component in the creation of drugs targeting nucleic acid-related processes.
Used in Chemical Synthesis:
In the field of chemical synthesis, 4-Amino-5-imidazolecarboxamide hydrochloride is utilized as a building block for the production of various heterocyclic compounds. Its unique structure allows for the development of novel compounds with potential applications in different industries, such as pharmaceuticals, agrochemicals, and materials science.
Used in Research and Development:
4-Amino-5-imidazolecarboxamide hydrochloride is employed as a research compound in academic and industrial laboratories. Its involvement in the synthesis of guanine, purines, and pyrimidines makes it a valuable tool for studying the structure, function, and interactions of these important biomolecules, ultimately contributing to advancements in various scientific fields.
Purification Methods
Recrystallise the hydrochloride from EtOH. [Kuroda & Hakko JEst(1) Est(2)Heterocycl Chem 30 593 1993, Alhede et al. J Org Chem 56 2139 1991, Cheru et al. Heterocycles 24 1133 1992, Beilstein 25 II 221, 25 III/IV 4329.]
Check Digit Verification of cas no
The CAS Registry Mumber 72-40-2 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 2 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 72-40:
(4*7)+(3*2)+(2*4)+(1*0)=42
42 % 10 = 2
So 72-40-2 is a valid CAS Registry Number.
InChI:InChI=1/C4H6N4O.ClH/c5-3-2(4(6)9)7-1-8-3;/h1H,5H2,(H2,6,9)(H,7,8);1H
72-40-2Relevant articles and documents
Development of a One-Step Synthesis of 5-Amino-1 H-imidazole-4-carboxamide
Qi, Ji,Yin, Jingjun,Li, Donghong,Chen, Song,Liu, Zhenguo
, p. 591 - 596 (2021/04/05)
An innovative and efficient synthesis of 5-amino-1H-imidazole-4-carboxamide (AIC) from commercially available hypoxanthine (~$30/kg) is described. The development of the key hydrolysis step and a practical isolation enables a highly efficient one-step manufacturing process for AIC with minimal environmental impact and significant reduction of production cost.