7259-53-2

Basic information

• Product Name: 4-benzylpyridine 1-oxide
• Synonyms: 4-Benzylpyridine 1-oxide; pyridine, 4-(phenylmethyl)-, 1-oxide
• CAS NO: 7259-53-2
• Molecular Formula: C₁₂H₁₁NO
• Molecular Weight: 185.2218
• Mol File: 7259-53-2.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 383.1°C at 760 mmHg
• Flash Point: 185.5°C
• Density: 1.04g/cm³
• Vapor Pressure: 9.93E-06mmHg at 25°C
• Refractive Index: 1.564
• CAS DataBase Reference: 4-benzylpyridine 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzylpyridine 1-oxide(7259-53-2)
• EPA Substance Registry System: 4-benzylpyridine 1-oxide(7259-53-2)

Safety Data

• Hazardous Substances Data: 7259-53-2(Hazardous Substances Data)

Upstream product

• 2116-65-6 4-benzyl pyridine 

Downstream Products

• 193204-91-0 4-benzyl-pyridine-2-carboxylic acid methyl ester 
• 59576-37-3 1-(4-benzylpyridin-2-yl)ethan-1-one 
• 127639-73-0 benzyl-2-(chloromethyl)pyridine 
• 127639-74-1 4-benzyl-2-(hydroxymethyl)pyridine 
• 33974-27-5 phenyl(pyridin-4-yl)methanol 
• 80099-88-3 (2-chloropyridin-4-yl)(phenyl)methanone 

Relevant articles and documents

Ozone-Mediated Amine Oxidation and Beyond: A Solvent-Free, Flow-Chemistry Approach

Ozone is a powerful oxidant, most commonly used for oxidation of alkenes to carbonyls. The synthetic utility of other ozone-mediated reactions is hindered by its high reactivity and propensity to overoxidize organic molecules, including most solvents. This challenge can largely be mitigated by adsorbing both substrate and ozone onto silica gel, providing a solvent-free oxidation method. In this manuscript, a flow-based packed bed reactor approach is described that provides exceptional control of reaction temperature and time to achieve improved control and chemoselectivity over this challenging transformation. A powerful method to oxidize primary amines into nitroalkanes is achieved. Examples of pyridine, C-H bond, and arene oxidations are also demonstrated, confirming the system is generalizable to diverse ozone-mediated processes.

URIDINE NUCLEOSIDE DERIVATIVES, COMPOSITIONS AND METHODS OF USE

This disclosure relates to uridine nucleoside derivatives, compositions comprising therapeutically effective amounts of those nucleoside derivatives and methods of using those nucleoside derivatives or compositions in treating disorders that are responsive to compounds, such as agonists, of P2Y6 receptor, e.g., neuronal disorders, including neurodegenerative disorders (e.g., Alzheimer's disease, Parkinson's disease) and traumatic CNS injury, pain, Down Syndrome (DS), glaucoma and inflammatory conditions.

Nickel-catalyzed C–H trifluoromethylation of pyridine N-oxides with Togni's reagent

The first nickel-catalyzed C–H trifluoromethylation of pyridine N-oxides with Togni's reagent has been achieved. Trifluoromethylation proceeds smoothly under mild conditions with moderate functional group compatibility. Notable advantages of this method include the using of low cost of nickel catalyst, and its simple convenient operation.