73512-12-6

Basic information

• Product Name: Furan, 2-bromo-5-phenyl-
• CAS NO: 73512-12-6
• Molecular Formula: C10H7BrO
• Molecular Weight: 223.069
• Mol File: 73512-12-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Furan, 2-bromo-5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Furan, 2-bromo-5-phenyl-(73512-12-6)
• EPA Substance Registry System: Furan, 2-bromo-5-phenyl-(73512-12-6)

Safety Data

• Hazardous Substances Data: 73512-12-6(Hazardous Substances Data)

Upstream product

• 591-50-4 iodobenzene 
• 17113-33-6 2-phenylfuran 

Downstream Products

• 94540-81-5 2-(4-methoxyphenyl)-5-phenylfuran 

Relevant articles and documents

TRANSCRIPTION FACTOR BRN2 INHIBITORY COMPOUNDS AS THERAPEUTICS AND METHODS FOR THEIR USE

The invention provides a variety of compounds having the structure of Formula I and uses of such compounds for treatment of various indications, including cancer as well as methods of treatment involving such compounds are also provided. The uses of the compounds may specifically include: bladder cancer, cholangiocarcinoma; colorectal cancer; diffuse large B-cell lymphoma (DLBC); liver cancer; ovarian cancer; thymoma; thyroid cancer; clear cell renal cell carcinoma (CCRCC); chromophobe renal cell carcinoma (ChRCC); prostate cancer; breast cancer; uterine cancer; pancreatic cancer; cervical cancer; uveal melanoma; acute myeloid leukemia (AML); head and neck cancer; small cell lung cancer (SCLC); lung adenocarcinoma sarcoma; mesothelioma; adenoid cystic carcinoma (ACC), sarcoma; testicular germ cell cancer; uterine cancer; pheochromocytoma and paraganglioma (PCPG); melanoma; glioma; glioblastoma multiforme; T-cell Acute Lymphoblastic Leukemia; T-cell Lympohoma, medulloblastoma; and neuroblastoma.

General facile synthesis of 2,5-diarylheteropentalenes

Palladium-catalyzed cross-coupling reactions of various heteropentalene derivatives were systematically studied. A general three-step synthesis of 2,5-diarylheteropentalenes involving two Suzuki or Negishi couplings and a regiospecific bromination was developed. Nonsymmetrical 2,5-diaryl-furans, thiophenes, pyrroles, 1,3-thiazoles, 1,3-oxazoles, 1,3,4-thiadiazoles, and 1,3,4-oxadiazoles were prepared in 31-67% isolated yield (three steps).