7361-61-7 Usage
Description
Xylazine, an analog of clonidine, is an agonist of α2-adrenergic receptors with a Ki value of 194 nM. It is soluble in methanol, dilute HCl acid, and chloroform, but practically insoluble in water and alkali solutions. Xylazine is primarily used for sedation, anesthesia, and analgesia in non-human mammals and is also available as an analytical reference standard.
Uses
Used in Veterinary Medicine:
Xylazine is used as a sedative and anesthetic agent for non-human mammals, providing calmness and reducing stress during medical procedures.
Used in Pain Management:
As an antinociceptive agent, Xylazine is employed to alleviate pain in non-human mammals by acting on the central nervous system.
Used in Pharmacology Research:
Xylazine serves as an α2 class of adrenergic receptor agonist, making it a valuable tool in pharmacological research for studying the effects and mechanisms of adrenergic receptor agonists.
Used in Drug Development:
As a clonidine analog, Xylazine is utilized in the development of new drugs targeting α2-adrenergic receptors, potentially leading to novel treatments for various conditions.
Originator
Xylazine,Bayer
Manufacturing Process
2,6-Dimethylphenyl isothiocyanate, 31.0 g (0.2 mole), prepared from 2,6-
dimethylaniline with thiophosgene, were added dropwise during 15 min to a
well-stirred suspension of 15.0 g (0.2 mole) of 3-aminopropanol-1 in 100 ml
of ether. The ether started to boil. Stirring under reflux was continued for 30
min, and the ether was then distilled off. The residue was treated with 100 ml
of concentrated hydrochloric acid and boiled under reflux for 30 min. After
cooling, it was diluted with water, filtered free from impurities, and the base
was precipitated by the addition of concentrated sodium hydroxide solution.
When recrystallized from benzene-ligroin, the resulting compound 2-(2,6-
dimethyl-phenylamino)-4H-5,6-dihydro-1,3-thiazine, melting point 140-142°C
(yield 90% of the theoretical).
Therapeutic Function
Analgesic, Anesthetic
Biochem/physiol Actions
Xylazine when used along with ketamine is considered to be a potent and safe anaesthetic in experimental animal. It is known to elevate the hepatic release of glucose, which aggravates to hyperglycemia.
Mechanism of action
Xylazine is marketed as its hydrochloride salt as Rompun (100 mg/mL) and
Anased (20 mg/mL) injectable solutions for intravenous administration to horses and dogs, respectively. The actions of xylazine may be reversed by the administration of yohimbine, an
indolalkylamine alkaloid, that blocks those α2-
adrenoreceptors that are stimulated by xylazine.
Safety Profile
Poison by ingestion,
subcutaneous, and intravenous routes.
Human systemic effects: change in motor
activity, fall in blood pressure, miosis,
pleural thickening, pulse rate decrease,
somnolence. When heated to decomposition
it emits very toxic fumes of NOx and SOx.
Check Digit Verification of cas no
The CAS Registry Mumber 7361-61-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,3,6 and 1 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 7361-61:
(6*7)+(5*3)+(4*6)+(3*1)+(2*6)+(1*1)=97
97 % 10 = 7
So 7361-61-7 is a valid CAS Registry Number.
InChI:InChI=1/C12H16N2S/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12/h3,5-6H,4,7-8H2,1-2H3,(H,13,14)
7361-61-7Relevant articles and documents
Chemical synthesis method of 2,6-dimethylaniline thiazine
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Paragraph 0027-0056, (2019/01/16)
The invention discloses a chemical synthesis method of 2,6-dimethylaniline thiazine. The method comprises the following steps: dissolving dried acetyl (2,6-dimethyl) aniline into an anhydrous solution; carrying out quantitative reaction on a mixed solution and carbon disulfide under the action of metal hydride to generate isothiocyanic acid-2,6-dimethyl phenyl ester; carrying out aminolysis on theisothiocyanic acid-2,6-dimethyl phenyl ester and 3-aminopropanol to obtain 1-(2,6-dimethyl)-phenyl-3-propanolyl thiourea after drying and purifying; and catalyzing and cyclizing with concentrated hydrochloric acid to obtain a target product 2,6-dimethylaniline thiazine. The preparation method disclosed by the invention has the advantages of easily-obtained raw materials, rigorous requirements onoperating conditions, simplicity in actual production and suitability for industrial mass production.
Process for the production of xylazine
-
, (2008/06/13)
In the preparation of 2,6-dimethylphenylisothiocyanate by reacting N-(2,6-dimethylphenyl)acetamide with sodium hydride in an organic solvent to form the corresponding anion of said amide, then reacting carbon disulfide with said anion to form said 2,6-dimethylphenylisothiocyanate, unexpectedly high yields are obtained by using as the organic solvent tetrahydrofuran or a mixture of N,N-dimethylacetamide and toluene. 2,6-Dimethylphenylisothiocyanate is an intermediate in the preparation of xylazine useful, for instance, as a sedative, an analgesic and muscle relaxant.