74014-51-0 Usage
Description
Rokitamycin, also known by its brand name RICAMYCIN, is a semisynthetic macrolide antibiotic that is closely related to miokamycin in both its chemical structure and antimicrobial spectrum. It is a pharmaceutical compound derived from natural macrolide antibiotics, which are known for their broad-spectrum antimicrobial properties.
Uses
Used in Pharmaceutical Industry:
Rokitamycin is used as an antibiotic for treating various bacterial infections. Its application is primarily due to its ability to inhibit bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome, thereby disrupting the translation process and stopping the growth of the bacteria.
Used in Research and Development:
In the field of research and development, rokitamycin is utilized as a starting material for the synthesis of other semisynthetic macrolide antibiotics. Its structural similarity to miokamycin allows for the exploration of new compounds with potentially improved antimicrobial properties or reduced side effects.
Used in Veterinary Medicine:
Rokitamycin is also employed in veterinary medicine as an antibiotic to treat bacterial infections in animals. Its broad-spectrum activity makes it a valuable tool in the treatment of various bacterial diseases in livestock and pets, contributing to the overall health and well-being of the animals.
Pharmaceutical Applications
3″-Propionyl leucomycin A5. A semisynthetic macrolide. Unstable in acid media. The antibacterial spectrum is identical to that of erythromycin, but it is less active against Gram-positive cocci. It is poorly active against H. influenzae (MIC50 8 mg/L) and Mor. catarrhalis (MIC50 4 mg/L). It displays good activity against Campylobacter spp. (MIC50 0.1 mg/L), L. pneumophila (MIC50 0.1 mg/L) and M. pneumoniae (MIC50 0.003 mg/L). It is active against anaerobes, including some Bacteroides spp. (MIC50 <0.05 mg/L).After a single oral dose of 600 mg, the peak plasma concentration was 1.9 mg/L after 0.6 h. Oral doses of 5, 10 and 15 mg/kg of a syrup formulation given to children achieved plasma concentrations of 0.26, 0.55 and 0.79 mg/L, respectively, after about 40 min. The half-life is around 2 h.It is mainly eliminated in the bile; only about 2% appears in the urine. Its major metabolites are leucomycin A7, 10″-OH-rokitamycin (which show some antibacterial activity) and leucomycin V. In healthy adult volunteers, the proportions of rokitamycin and its metabolites in serum 30 min after a single oral dose of 1200 mg were 18% (leucomycin A7), 33% (10″-OH-rokitamycin) and 9% (leucomycin V). The pharmacokinetic behavior is not altered in patients with liver cirrhosis. It is available in Italy and Japan.
Check Digit Verification of cas no
The CAS Registry Mumber 74014-51-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,0,1 and 4 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 74014-51:
(7*7)+(6*4)+(5*0)+(4*1)+(3*4)+(2*5)+(1*1)=100
100 % 10 = 0
So 74014-51-0 is a valid CAS Registry Number.
InChI:InChI=1/C42H69NO15/c1-11-16-32(48)55-40-27(6)53-34(23-42(40,7)58-31(47)12-2)56-37-26(5)54-41(36(50)35(37)43(8)9)57-38-28(19-20-44)21-24(3)29(45)18-15-13-14-17-25(4)52-33(49)22-30(46)39(38)51-10/h13-15,18,20,24-30,34-41,45-46,50H,11-12,16-17,19,21-23H2,1-10H3/b14-13+,18-15+/t24-,25-,26-,27+,28+,29+,30-,34+,35-,36-,37-,38+,39+,40+,41+,42-/m1/s1