74088-75-8

Basic information

• Product Name: 3-isopropyl-5-(2-methyl-3-nitrophenoxymethyl)-oxazolidin-2-one
• Synonyms: 3-isopropyl-5-(2-methyl-3-nitrophenoxymethyl)-oxazolidin-2-one
• CAS NO: 74088-75-8
• Molecular Weight: 294.307
• Mol File: 74088-75-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-isopropyl-5-(2-methyl-3-nitrophenoxymethyl)-oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-isopropyl-5-(2-methyl-3-nitrophenoxymethyl)-oxazolidin-2-one(74088-75-8)
• EPA Substance Registry System: 3-isopropyl-5-(2-methyl-3-nitrophenoxymethyl)-oxazolidin-2-one(74088-75-8)

Safety Data

• Hazardous Substances Data: 74088-75-8(Hazardous Substances Data)

Upstream product

• 81102-68-3 Toluene-4-sulfonic acid (S)-2-hydroxy-3-(2-methyl-3-nitro-phenoxy)-propyl ester 
• 81102-65-0 (S)-2,2-Dimethyl-4-(2-methyl-3-nitro-phenoxymethyl)-[1,3]dioxolane 
• 81102-66-1 <2R>-3-(2-methyl-3-nitrophenoxy)-1,2-propanediol 
• 81132-32-3 <2R>-(+)-1-isopropylamino-3-(2-methyl-3-nitrophenoxy)-2-propanol 
• 616-38-6 carbonic acid dimethyl ester 

Downstream Products

• 13523-86-9 1-(1H-indol-4-yloxy)-3-(isopropylamino)-2-propanol 
• 81745-07-5 5-[2-((E)-2-Dimethylamino-vinyl)-3-nitro-phenoxymethyl]-3-isopropyl-oxazolidin-2-one 

Relevant articles and documents

Practical Syntheses of - and -1-Alkylamino-3-aryloxy-2-porpanols from a Single Carbohydrate Precursor

A practical synthetic route to optically active - and -1-alkylamino-3-aryloxy-2-propanols (β-blockers) from -2,3-O-isopropylideneglyceraldehyde (-1) was developed.Synthesis of the -isomers was carried out as follows.Borohydride reduction of -1 in the presence of excess alkylamine followed by alkoxycarbonylation, acid hydrolysis, and cyclization under K2CO3 catalysis gave -3-alkyl-5-hydroxymethyl-1,3-oxazolidin-2-ones, the tosylates of which were coupled with various phenols then hydrolyzed by alkali treatment to give -(-)-β-blockers (e.g., propranolol, carteolol) in satisfactory yields. -,-, and rac-pindolol were synthesized from the corresponding 3-isopropyl-5-(2-methyl-3-nitrophenoxymethyl)-1,3-oxazolidin-2-one by application of the Leimgruber-Batcho method.Keywords--- and -1-alkylamino-3-aryloxy-2-propanols; optically active β-blockers; propranolol; carteolol; pindolol; carbohydrate precursor; -2,3-O-isopropylideneglyceraldehyde; -3-alkyl-5-hydroxymethyl-1,3-oxazolidin-2-ones; Leimgruber-Batcho indole synthesis