7417-19-8

Basic information

• Product Name: 2,5-dimethoxyphenethyl alcohol
• Synonyms: 2,5-dimethoxyphenethyl alcohol;2-(2,5-DIMETHOXYPHENYL)ETHANOL;2,5-Dimethoxybenzeneethanol
• CAS NO: 7417-19-8
• Molecular Formula: C₁₀H₁₄O₃
• Molecular Weight: 182.21636
• EINECS: 231-030-4
• Mol File: 7417-19-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 275.62°C (rough estimate)
• Flash Point: 133.1°C
• Appearance: /
• Density: 1.0550
• Vapor Pressure: 0.000645mmHg at 25°C
• Refractive Index: 1.5395 (estimate)
• PKA: 14.79±0.10(Predicted)
• CAS DataBase Reference: 2,5-dimethoxyphenethyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-dimethoxyphenethyl alcohol(7417-19-8)
• EPA Substance Registry System: 2,5-dimethoxyphenethyl alcohol(7417-19-8)

Safety Data

• Hazardous Substances Data: 7417-19-8(Hazardous Substances Data)

Usage

General Description

2,5-dimethoxyphenethyl alcohol is a chemical compound known for its psychoactive properties. It belongs to the class of phenethylamines and is derived from the compound 2C-H. It has been used in the production of psychoactive drugs and has been studied for its potential medicinal uses. Its psychoactive effects include hallucinogenic and mind-altering properties, and it may also have potential as a treatment for certain mental health conditions. However, its use is highly regulated and it is considered a controlled substance in many countries due to its potential for abuse and harmful effects on physical and mental health.

InChI:InChI=1/C10H14O3/c1-12-9-3-4-10(13-2)8(7-9)5-6-11/h3-4,7,11H,5-6H2,1-2H3

Upstream product

• 52711-92-9 2,5-dimethoxyphenylacetyl chloride 
• 1201-38-3 2',5'-dimethoxyacetophenone 
• 24599-58-4 2,5-dimethoxy toluene 
• 60732-17-4 2,5-dimethoxybenzyl bromide 
• 116632-49-6 (2,5-dimethoxy-phenyl)-pyruvic acid 
• 18086-24-3 2-(2,5-dimethoxyphenyl)acetonitrile 
• 75-21-8 oxirane 
• 66469-86-1 ethyl (2,5-dimethoxyphenyl)acetate 
• 74-85-1 ethene 
• 150-78-7 1,4-dimethoxybezene 
• 82301-18-6 propyl 2,5-dimethoxyphenylacetate 
• 109-72-8 n-butyllithium 
• 1758-25-4 (2,5-dimethoxyphenyl)acetic acid 
• 64-17-5 ethanol 

Downstream Products

• 256343-36-9 2-(4-iodo-2,5-dimethoxyphenyl)ethanol 
• 1259330-61-4 sparstolonin B 
• 184473-60-7 2-(4-bromo-2,5-dimethoxyphenyl)ethanol 
• 681171-54-0 [2-(2,5-dimethoxy-phenyl)-ethoxy]-dimethyl-silane 
• 38843-76-4 4-Brom-2,5-dimethoxyphenethylcarbamat 
• 38843-55-9 Carbamic acid 2-(4-bromo-3,6-dioxo-cyclohexa-1,4-dienyl)-ethyl ester 
• 66397-42-0 Ethyl-2.6-dimethyl-8-(2'.5'-dimethoxyphenyl)octa-2E_.6E-dienoat 
• 50628-18-7 2,6-dimethyl-8-(2,5-dimethoxyphenyl)octa-2,6-dienal 
• 66397-43-1 8-(2,5-dimethoxyphenyl)-2,6-dimethylocta-2,6-dienol 
• 66397-40-8 2-Methyl-3-vinyloxy-4-(2',5'-dimethoxyphenyl)-but-1-en 
• 66397-39-5 2-Methyl-3-hydroxy-4-(2',5'-dimethoxyphenyl)-but-1-en 

Relevant articles and documents

Total synthesis of sparstolonin B via a palladium-catalyzed aldehyde α-arylation

A concise and convergent total synthesis of sparstolonin B was developed. A palladium-catalyzed aldehyde α-arylation was utilized to construct the carbon skeleton of the natural product. A subsequent simple one-pot procedure effected global deprotection and closure of the final two rings via an unusual autoredox mechanism for the conversion of a bis-hydroquinone intermediate to the natural product. The 6 step synthetic sequence was realized in 18% overall yield.

Inhibitors of c-Jun N-terminal kinases

The present invention relates to compounds that are inhibitors of c-jun N-terminal kinase 1, 2, or 3 (JNK1, JNK2, or JNK3), compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the activation of JNK1, JNK2 and JNK3.

High pressure nucleophilic fluoride-ion substitution reactions: Formation of fluoroalkylbenzenes

A series of 1-phenyl-2-tosyloxy- and 1-phenyl-3-tosyloxyalkanes was synthesized and then subjected to tetrabutylammonium fluoride in THF under 15 kbar (1.5 GPa), 8 kbar or 1 bar pressures. The resultant substitution and elimination reaction product distributions were analyzed. The application of pressure enhanced the progress of the fluoride-ion substitution reactions. The degree of selectivity of the one reaction over the other was found to be a function of tosylate substrate structure and the amount of pressure applied. The exclusive formation of fluoroalkanes from 1-phenyl-2-tosyloxyalkane substrates under 15 kbar pressure demonstrated the potential of the pressure method for prospective use in fluorine-18 radiolabelling applications.