749886-87-1 Usage
Description
4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE, also known as JSH-23, is a cell-permeable diamino compound that selectively blocks nuclear translocation of NF-κB p65 and its transcription activity. It has an IC50 of 7.1 μM in a NF-κB reporter assay using RAW 264.7 cells and does not affect IκB degradation. JSH-23 has been shown to suppress DNA-binding of NF-κB and downregulate LPS-induced gene expression and apoptotic chromatin condensation.
Uses
Used in Pharmaceutical Industry:
4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE is used as a nuclear factor κB (NF-κB) p65 inhibitor for its ability to selectively block nuclear translocation of NF-κB p65 and suppress its transcription activity. This makes it a potential candidate for the development of drugs targeting inflammatory and immune response pathways.
Used in Research Applications:
4-METHYL-N1-(3-PHENYLPROPYL)BENZENE-1,2-DIAMINE is used as a research tool for studying the role of NF-κB in various cellular processes, including inflammation, immune response, and cell survival. Its ability to selectively block NF-κB p65 translocation and suppress its transcription activity makes it a valuable compound for investigating the molecular mechanisms underlying these processes.
Biological Activity
jsh-23 is an inhibitor of nf-κb transcriptional activity with ic50 value of 7.1μm [1].jsh-23 is developed to inhibit nf-κb transcriptional activity in lps-stimulated macrophages raw 264.7. it shows a dose-dependent inhibition. this effect is not due to its cytotoxicity. in the same condition, jsh-23 is found to significantly decrease the lps-induced dna binding activity of nf-κb while decrease nuclear amount of nf-κb p65. jsh-23 plays these roles without affecting iκb degradation. in addition, jsh-23 also shows inhibition effects on the expression of the pro-inflammatory transcripts and enzymes, including il-6, il-1β, cox-2 and tnf-α. furthermore, jsh-23 inhibits lps-induced apoptotic chromatin condensation [1].
Biochem/physiol Actions
Primary TargetBlocks nuclear translocation of NF-κB p65 and its transcription activity
references
[1] shin hm, kim mh, kim bh, jung sh, kim ys, park hj, hong jt, min kr, kim y. inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of nf-kappab without affecting ikappab degradation. febs lett. 2004 jul 30;571(1-3):50-4.
Check Digit Verification of cas no
The CAS Registry Mumber 749886-87-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,4,9,8,8 and 6 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 749886-87:
(8*7)+(7*4)+(6*9)+(5*8)+(4*8)+(3*6)+(2*8)+(1*7)=251
251 % 10 = 1
So 749886-87-1 is a valid CAS Registry Number.
InChI:InChI=1/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3
