75235-71-1Relevant articles and documents
Aromatic heterocyclic borate and its preparation method, use (by machine translation)
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Paragraph 0069-0073, (2017/06/02)
The invention relates to a hydroxyalkylation heterocyclic borate and its preparation method, use; said additive structural formula such as formula (I) or (II) shown; the invention also relates to the above-mentioned aromatic heterocyclic borate lubricating additive preparation method, the method comprises the following steps: step a, in the organic solvent and catalyst under the condition of, heterocyclic compounds and alkyl epoxide reaction, generating compounds A; make stated, in the organic solvent and catalyst under the condition of the, compound B with compound A, or by the reaction of the cyclic ethers, can be; the invention also relates to the use of alkylated heterocyclic borate fore-mentioned hydroxy. (by machine translation)
Asymmetric reduction of 1-(benzoazol-2-ylsulfanyl)propan-2-ones using whole cells of Mortierella isabellina, Debaryomyces hansenii, Geotrichum candidum and Zygosaccharomyces rouxii
Borowiecki, Pawel,Wloczewska, Malgorzata,Ochal, Zbigniew
, p. 9 - 16 (2015/01/09)
Growing cells of four fungal strains were used in reduction of 1-(benzoazol-2-ylsulfanyl)propan-2-ones3a-c to corresponding (R)-(+)-1-(benzoazol-2-ylsulfanyl)propan-2-ols (R)-(+)-4a-c. All of the investi-gated yeast strains displayed a very high activity toward prochiral ketones 3a-c converting them tothe desired alcohols after relatively short reaction time (1-3.5 h). The biotransformation products wereisolated with moderate to good yields (45-89%) and in highly enantioenriched forms (94-99% ee). Ste-reoselective bioreduction of 1-(1H-benzimidazol-2-ylsulfanyl)propan-2-one 3a by D. hansenii DSM 3428growing cells provided the respective (R)-alcohol with >99% yield, in reasonable 65% isolated yield andin a highly stereoselective manner (98% ee) after 3 h of cultivation. In the same culture, bioreduction of1-(1,3-benzoxazol-2-ylsulfanyl)propan-2-one 3b led to a 76% yield, 65% isolated yield and very high 94%ee of the formed (R)-alcohol. Similar 1.5 h incubation of 1-(1,3-benzothiazol-2-ylsulfanyl)propan-2-one3c in G. candidum LOCK 105 culture resulted in the corresponding (R)-alcohol preparation in moderate45% isolated yield with excellent enantiomeric purity (99% ee).