75566-54-0

Basic information

• Product Name: 2-hydroxymethyl-7-methoxy-benzofuran
• CAS NO: 75566-54-0
• Molecular Weight: 178.188
• Mol File: 75566-54-0.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 2-hydroxymethyl-7-methoxy-benzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxymethyl-7-methoxy-benzofuran(75566-54-0)
• EPA Substance Registry System: 2-hydroxymethyl-7-methoxy-benzofuran(75566-54-0)

Safety Data

• Hazardous Substances Data: 75566-54-0(Hazardous Substances Data)

Upstream product

• 88234-77-9 7-Methoxybenzofuran-2-carbaldehyde 
• 1060729-00-1 7-methoxy-2-methylene-2,3-dihydro-1-benzofuran-3-ol 
• 50551-58-1 ethyl 7-methoxybenzofuran-2-carboxylate 
• 59254-09-0 2-carbomethoxy-7-methoxybenzofuran 
• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 4790-79-8 7-methoxybenzofuran-2-carboxylic acid 

Downstream Products

• 88234-77-9 7-Methoxybenzofuran-2-carbaldehyde 
• 29025-30-7 7-methoxy-2-methylbenzo[b]furan 
• 258872-65-0 7-Hydroxy-2-hydroxymethyl-benzofuran 

Relevant articles and documents

Synthesis of Indole/Benzofuran-Containing Diarylmethanes through Palladium-Catalyzed Reaction of Indolylmethyl or Benzofuranylmethyl Acetates with Boronic Acids

The palladium-catalyzed synthesis of indole/benzofurancontaining diarylmethanes starting from indolylmethyl or benzofuranylmethyl acetates with boronic acids has been investigated. The success of the reaction is influenced by the choice of precatalyst: with indolylmethyl acetates the reaction works well with [Pd(η3-C3H5)Cl]2/XPhos while with benzofuranylmethyl acetates Pd2(dba)3/XPhos is more efficient. The good to high yields and the simplicity of the experimental procedure make this protocol a versatile synthetic tool for the preparation of 2- and 3-substituted indoles and 2-benzo[b]furans. The methodology can be advantageously extended to the preparation of a key precursor of Zafirlukast.

Chromium-Catalyzed Asymmetric Dearomatization Addition Reactions of Halomethyl Heteroarenes

The first asymmetric dearomatization addition reaction of halomethyl arenes including benzofuran and benzothiophene was enabled by chromium catalysis. A variety of aldehydes served as suitable electrophiles under mild reaction conditions. Molecular complexities are quickly increased in a highly diastereo- and enantioselective manner.

TREATMENT OR PROPHYLAXIS OF PROLIFERATIVE CONDITIONS

The invention relates to novel compounds for use in the treatment or prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express cytochrome P450 1B1 (CYP1B1) and allelic variants thereof. The invention also provides pharmaceutical compositions comprising one or more such compounds for use in medical therapy, for example in the treatment of prophylaxis of cancers or other proliferative conditions, as well as methods for treating cancers or other conditions in human or non-human animal patients. The invention also provides methods for identifying novel compounds for use in the treatment of prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express CYP1 B1 and allelic variants thereof. The invention also provides a method for determining the efficacy of a compound of the invention in treating cancer.