76008-73-6

Basic information

• Product Name: ETHYL 5-BROMO-2-CHLOROBENZOATE
• Synonyms: Ethyl 5-bromo-2-chlorobenzoate, 98+%;Ethyl 5-bromo2-chlorobenzaldehyde;Ethyl 5-bromo-2-chlorobenzoate,97%;2-chloro-5-broMobenzoic acid ethyl ester;5-broMo-2-chloro-3-ethylbenzaldehyde;5-BROMO-2-CHLOROBENZOIC ACID ETHYL ESTER;LABOTEST-BB LT01148052;ETHYL 5-BROMO-2-CHLOROBENZOATE
• CAS NO: 76008-73-6
• Molecular Formula: C₉H₈BrClO₂
• Molecular Weight: 263.52
• Product Categories: Aromatic Esters;Benzoic acid;Acids & Esters;Bromine Compounds;Chlorine Compounds;C8 to C9;Carbonyl Compounds;Esters
• Mol File: 76008-73-6.mol
• Article Data: 8

Chemical Properties

• Melting Point: 128-130 °C
• Boiling Point: 288 °C(lit.)
• Flash Point: >230 °F
• Appearance: Clear light yellow/Liquid
• Density: 1.55 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0019mmHg at 25°C
• Refractive Index: n20/D 1.56(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 6501991
• CAS DataBase Reference: ETHYL 5-BROMO-2-CHLOROBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 5-BROMO-2-CHLOROBENZOATE(76008-73-6)
• EPA Substance Registry System: ETHYL 5-BROMO-2-CHLOROBENZOATE(76008-73-6)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/22-22-20
• Safety Statements: 45-36/37/39-37/38/46-36
• WGK Germany: 3
• Hazardous Substances Data: 76008-73-6(Hazardous Substances Data)

Usage

Description

ETHYL 5-BROMO-2-CHLOROBENZOATE is an organic compound characterized by its white to light yellow crystal powder appearance. It is a derivative of benzoic acid with a bromine atom at the 5th position and a chlorine atom at the 2nd position, attached to an ethyl ester group. This chemical structure endows it with specific properties that make it suitable for various applications in different industries.

Uses

Used in Pharmaceutical Industry:
ETHYL 5-BROMO-2-CHLOROBENZOATE is used as an intermediate compound for the synthesis of ethyl 6-bromo-3-chloro-3′-methylbiphenyl-2-carboxylate, which can be further utilized in the development of pharmaceutical products. Its unique chemical structure allows it to serve as a building block for the creation of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, ETHYL 5-BROMO-2-CHLOROBENZOATE is used as a key reactant in the production of various organic compounds. Its bromine and chlorine atoms can participate in a range of chemical reactions, such as substitution, addition, and elimination, enabling the synthesis of a wide array of molecules with diverse properties and applications.
Used in Research and Development:
Due to its unique chemical structure, ETHYL 5-BROMO-2-CHLOROBENZOATE is also employed in research and development laboratories. It can be used as a model compound to study various chemical reactions and mechanisms, as well as to test new synthetic methods and techniques. This helps researchers gain a better understanding of the underlying principles of organic chemistry and develop more efficient and environmentally friendly synthetic processes.

InChI:InChI=1/C9H8BrClO2/c1-2-13-9(12)7-5-6(10)3-4-8(7)11/h3-5H,2H2,1H3

Upstream product

• 24398-88-7 ethyl 3-bromobenzoate 
• 118-91-2 ortho-chlorobenzoic acid 
• 64-17-5 ethanol 
• 21739-92-4 5-bromo-2-chlorobenzoic acid 

Downstream Products

• 149965-40-2 5-bromo-2-chlorobenzyl alcohol 
• 1031418-04-8 ethyl 2-chloro-5-(2-(trimethylsilyl)ethynyl)benzoate 
• 461432-25-7 (2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate 
• 301673-17-6 (+/-)-2-chloro-5-[3-[[(1,1-dimethylethoxy)carbonyl]amino]-1-pyrrolidinyl]-benzoic acid 
• 301672-72-0 2-chloro-5-[4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-piperidinyl]-benzoic acid 
• 301672-69-5 4-(3-Carboxy₄-chlorophenyl)hexahydro-1H-1,4-diazepine-1-carboxylic acid, 1,1-dimethylethyl ester 
• 301672-75-3 (+/-)-[1-[4-chloro-3-[[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]carbonyl]phenyl]-3-pyrrolidinyl]-carbamic acid, 1,1-dimethylethyl ester 
• 301672-73-1 [1-[4-chloro-3-[[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]carbonyl]phenyl]-4-piperidinyl]-carbamic acid, 1,1-dimethylethyl ester 
• 301673-05-2 4-[4-Chloro-3-[[(2-tricyclo[3.3.1.13,7]dec-1-ylethyl)amino]carbonyl]phenyl]hexahydro-1H-1,4-diazepine-1-carboxylic acid, 1,1-dimethylethyl ester 
• 885067-50-5 ethyl 2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate 
• 885067-51-6 4,3'-dichloro-biphenyl-3,4'-dicarboxylic acid diethyl ester 
• 309712-88-7 4-(4-chloro-3-ethoxycarbonyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 31121-43-4 2-deuterio ethyl benzoate 
• 93-89-0 benzoic acid ethyl ester 

Relevant articles and documents

Diamine as well as preparation method and application thereof (by machine translation)

The structural formula of the diamine is shown as a formula (I). The invention also discloses a preparation method of the diamine, which comprises the following steps: 2 - chlorine -5 - bromobenzoate and magnesium metal; a metallization reaction occurs un

Design, synthesis, insecticidal activity and 3D-QSR study for novel trifluoromethyl pyridine derivatives containing an 1,3,4-oxadiazole moiety

A series of trifluoromethyl pyridine derivatives containing 1,3,4-oxadiazole moiety was designed, synthesized and bio-assayed for their insecticidal activity. The result of bio-assays indicated the synthesized compounds exhibited good insecticidal activity against Mythimna separata and Plutella xylostella, most of the title compounds show 100% insecticidal activity at 500 mg L-1 and >80% activity at 250 mg L-1 against the two pests. Compounds E18 and E27 showed LC50 values of 38.5 and 30.8 mg L-1 against Mythimna separata, respectively, which were close to that of avermectin (29.6 mg L-1); compounds E5, E6, E9, E10, E15, E25, E26, and E27 showed 100% activity at 250 mg L-1, which were better than chlorpyrifos (87%). CoMFA and CoMSIA models with good predictability were proposed, which revealed the electron-withdrawing groups with an appropriate bulk at 2- and 4-positions of benzene ring could enhance insecticidal activity.

4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes

The invention relates to 4-methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalene derivatives of general formula (I) which are inhibitors of phosphodiesterase 2 and/or 10, useful in treating central nervous system diseases and other diseases. In addition, the invention relates to processes for preparing pharmaceutical compositions as well as processes for manufacture the compounds according to the invention.