769950-62-1

Basic information

• Product Name: ({3,5-bis-[2-(tert-butoxycarbonyl-methyl-amino)-acetylamino]-cyclohexylcarbamoyl}-methyl)-methyl-carbamic acid tert-butyl ester
• Synonyms: ({3,5-bis-[2-(tert-butoxycarbonyl-methyl-amino)-acetylamino]-cyclohexylcarbamoyl}-methyl)-methyl-carbamic acid tert-butyl ester
• CAS NO: 769950-62-1
• Molecular Weight: 642.794
• Mol File: 769950-62-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ({3,5-bis-[2-(tert-butoxycarbonyl-methyl-amino)-acetylamino]-cyclohexylcarbamoyl}-methyl)-methyl-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: ({3,5-bis-[2-(tert-butoxycarbonyl-methyl-amino)-acetylamino]-cyclohexylcarbamoyl}-methyl)-methyl-carbamic acid tert-butyl ester(769950-62-1)
• EPA Substance Registry System: ({3,5-bis-[2-(tert-butoxycarbonyl-methyl-amino)-acetylamino]-cyclohexylcarbamoyl}-methyl)-methyl-carbamic acid tert-butyl ester(769950-62-1)

Safety Data

• Hazardous Substances Data: 769950-62-1(Hazardous Substances Data)

Upstream product

• 80621-90-5 tert-butyl N-{2-[(2,5-dioxopyrrolidin-1-yl)oxy]-2-hydroxyethyl}-N-methylcarbamate 
• 58632-95-4 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile 
• 13734-36-6 N-(tert-butoxycarbonyl)sarcosine 

Relevant articles and documents

Evaluation of chelating agents as anti-angiogenic therapy through copper chelation

A set of novel polyamine hexadentate cis,cis-1,3,5,-triaminocyclohexane (tach) chelating agents were synthesized and evaluated in conjunction with a selection of both linear and macrocyclic polyamines as copper chelators for novel anti-angiogenic therapy in an in vitro endothelial cell proliferation assay to assess their cytotoxicity and selectivity. Macrocyclic polyamine 15 exhibited the greatest selective activity in this assay while the tach based ligands exhibited cytotoxicity, but no selectivity. The evaluation of several sets of polyamine donor chelating agents including a selection of novel hexadentate 1,3,5-cis,cis-triaminocyclohexane (tach) based derivatives were performed in an in vitro endothelial cell proliferation assay to assess their cytotoxicity and selectivity as novel anti-angiogenic agents. The selective nature of the anti-angiogenic agents for human umbilical vein endothelial cells (HUVEC) was compared to a normal fibroblast cell line and a human Glioma cell line to evaluate these compounds. Linear tri- and tetra-polyamines were superior to both macrocyclic and the tach based polyamine chelating agents in terms of selectivity of its inhibitory activity toward the proliferation of HUVEC cells compared to the fibroblast and human Glioma cells. The linear polyamine, triethylenetetramine (22), previously reported to possess anti-angiogenic properties failed to demonstrate any selectivity for inhibiting the proliferation of HUVEC cells compared to the fibroblast and human Glioma cells.