77-89-4 Usage
Description
Triethyl acetyl citrate (ATEC) is a clear, odorless, and practically colorless oily liquid that is produced by the reaction of citric acid triethyl ester with acetic acid anhydride. It is widely used in various industries due to its versatile properties.
Uses
Used in Plasticizer Industry:
Triethyl acetyl citrate is used as a solvent plasticizer for cellulose nitrate and cellulose acetate, enhancing the flexibility and workability of these materials.
Used in Pharmaceutical Industry:
ATEC is used as a pharmaceutical secondary standard, providing a convenient and cost-effective alternative for quality control in pharmaceutical laboratories and manufacturing.
Used in Hydrophilic Adhesives for Medications:
Triethyl acetyl citrate is used as a component in hydrophilic adhesives for medications, improving the adhesion and performance of these products.
Used in Biodegradable Composition for Papermaking and Nonwoven Production:
ATEC is utilized in the composition of biodegradable materials for papermaking and nonwoven production, contributing to the development of eco-friendly and sustainable products.
Used in the Preparation of Poly(lactic) Acid Films:
Triethyl O-Acetylcitrate is used in the preparation of poly(lactic) acid biodegradable and flexible films, acting as a plasticizer to improve the flexibility and performance of these films.
Used in Synthesis of Control-Release Capsules:
Triethyl acetyl citrate is also used in the synthesis of control-release capsules containing polymeric coatings, enhancing the controlled release of active ingredients in pharmaceutical applications.
Used in Aqueous-Based Pharmaceutical Coatings:
ATEC is employed in the development of aqueous-based pharmaceutical coatings, providing a stable and efficient method for coating pharmaceutical products.
Production Methods
Acetyltriethyl citrate is prepared by the esterification of citric acid
with ethanol followed by acylation with acetic anhydride.
Pharmaceutical Applications
Acetyltriethyl citrate is used to plasticize polymers in formulated
pharmaceutical coatings. The coating applications include
capsules, tablets, beads and granules for taste masking, immediate
release, sustained-release and enteric formulations. It is also
used in diffusion-controlled release drug delivery systems.
Safety
Acetyltriethyl citrate is used in oral pharmaceutical formulations
and is generally regarded as a nontoxic and nonirritating material.
However, ingestion of large quantities may be harmful.
LD50 (cat, oral): 8.5 g/kg
LD50 (mouse, IP): 1.15 g/kg
LD50 (rat, oral): 7 g/kg
storage
Acetyltriethyl citrate should be stored in dry, closed containers at
temperatures not exceeding 388℃. When stored in accordance with
these conditions, acetyltriethyl citrate is a stable product.
Incompatibilities
Acetyltriethyl citrate is incompatible with strong alkalis and
oxidizing materials.
Regulatory Status
Approved in the USA for direct food contact in food films.
Check Digit Verification of cas no
The CAS Registry Mumber 77-89-4 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 7 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 77-89:
(4*7)+(3*7)+(2*8)+(1*9)=74
74 % 10 = 4
So 77-89-4 is a valid CAS Registry Number.
InChI:InChI=1/C14H22O8/c1-5-19-11(16)8-14(22-10(4)15,13(18)21-7-3)9-12(17)20-6-2/h5-9H2,1-4H3
77-89-4Relevant articles and documents
manufacturing method of acetyl-triethyl citrate using solid acid catalysts
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Paragraph 0044-0048; 0079, (2018/04/20)
The present invention relates to a method for producing acetyl triethyl citrate using a solid acid catalyst and, more specifically, to a method for producing acetyl triethyl citrate capable of increasing conversion rate of reactants while improving yield of acetyl triethyl citrate using zeolite as a catalyst. To this end, the method for producing the acetyl triethyl citrate comprises the following steps: an insertion step for inserting triethyl citrate and acetic anhydride into a reactor; and a reaction step for producing acetyl triethyl citrate by carrying out a reaction between triethyl citrate and acetic anhydride in the presence of the solid acid catalyst.COPYRIGHT KIPO 2017
SKIN EXTERNAL PREPARATIONS AND COSMETICS
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, (2010/12/29)
An object of the present invention is to provide skin external preparations and cosmetics which contain a branched acyl carnitine and have excellent formulation stability. A skin external preparation of the present invention includes a carnitine derivative represented by the following Formula (1) and/or a carnitine derivative salt represented by the following Formula (2), and an amphoteric surfactant. In Formula (1), R1 and R2 are each independently a C1-18 optionally branched, saturated or unsaturated aliphatic hydrocarbon group. In Formula (2), R1 and R2 are the same as in Formula (1), X? is a specific anion and Y+ is a specific cation.