78477-43-7

Basic information

• Product Name: 4-(5-METHYL-FURAN-2-YL)-BENZONITRILE
• Synonyms: 4-(5-METHYL-2-FURYL)BENZONITRILE;4-(5-METHYL-FURAN-2-YL)-BENZONITRILE
• CAS NO: 78477-43-7
• Molecular Formula: C₁₂H₉NO
• Molecular Weight: 183.21
• Mol File: 78477-43-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(5-METHYL-FURAN-2-YL)-BENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-METHYL-FURAN-2-YL)-BENZONITRILE(78477-43-7)
• EPA Substance Registry System: 4-(5-METHYL-FURAN-2-YL)-BENZONITRILE(78477-43-7)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 78477-43-7(Hazardous Substances Data)

Upstream product

• 534-22-5 2-methylfuran 
• 623-26-7 terephthalonitrile 
• 67-56-1 methanol 
• 78370-57-7 2-methyl-2-methoxy-5-(4-cyanophenyl)-2,5-dihydrofuran 
• 946401-57-6 4-(1,4-dihydroxypent-2-ynyl)benzonitrile 
• 64-04-0 phenethylamine 
• 105-07-7 4-cyanobenzaldehyde 
• 623-00-7 4-bromobenzenecarbonitrile 
• 49584-26-1 p-cyanobenzenesulfonyl chloride 
• 873-74-5 4-Aminobenzonitrile 

Relevant articles and documents

Direct (Hetero)arylation of Heteroarenes Catalyzed by Unsymmetrical Pd-PEPPSI-NHC Complexes under Mild Conditions

With the aim of developing a facile and efficient method to access structurally intriguing and valuable functionalized (hetero)aryls, two unsymmetrical Pd-PEPPSI-type NHC complexes (PEPPSI, pyridine-enhanced precatalyst preparation, stabilization, and initiation; NHC, N-heterocyclic carbene) were designed and synthesized to catalyze the direct arylation of heteroarenes with (hetero)aryl bromides. The results demonstrated that the utilization of this "unsymmetrical"strategy led to much higher efficiency in comparison to the commonly used C2-symmetric Pd-PEPPSI-type NHC complexes. Furthermore, a broad range of heteroaromatics and (hetero)aryl bromide partners with a wide variety of functional groups were all amenable to the developed protocol even at as low as 0.05 mol % catalyst loading and under aerobic conditions. More importantly, along with our study, we also found that the present protocol could provide expedient access to the gram-scale synthesis of the muscle relaxant drug dantrolene and conjugated mesopolymers.

AgONO-Assisted Direct C-H Arylation of Heteroarenes with Anilines

A novel copper-catalyzed C-H arylation of heteroarenes with anilines by an in situ diazonium reaction is established by using silver nitrite (AgONO) as an unconventional nitrosating reagent under acid-free conditions. It provides a complementary approach for the C-H arylation of electron-rich heteroarenes with aromatic amines affording a variety of heterobiaryls in moderate to good yields.

Synthesis of furans, pyrroles and pyridazines by a ruthenium-catalysed isomerisation of alkynediols and in situ cyclisation

Alkyne-1,4-diols are readily available substrates which are isomerised to 1,4-diketones using Ru(PPh3)3(CO)H2/xantphos as a catalyst. In situ cyclisation into furans, pyrroles and pyridazines has been achieved under suitable conditions.