80-99-9 Usage
Description
Lathosterol, also known as 5α-Cholest-7-en-3β-ol, is a cholesterol synthesis precursor and a cholestanoid that is (5alpha)-cholest-7-ene substituted by a beta-hydroxy group at position 3. It plays a crucial role in cholesterol metabolism and serves as a biomarker for cholesterol synthesis and absorption.
Uses
Used in Health Assessment:
Lathosterol is used as a biomarker for cholesterol synthesis and absorption, indicating deteriorating health when its levels decrease along with sitosterol and cholesterol. Low levels of lathosterol, sitosterol, and cholesterol predict mortality additively and independently of each other.
Used in Cholesterol and Plant Sterols Estimation:
Lathosterol has been used as a standard for estimating the concentrations of cholesterol and plant sterols, helping in the assessment of cholesterol metabolism and related health conditions.
Used in Enzymatic Assays:
5α-Cholest-7-en-3β-ol, the chemical name for lathosterol, is used as a substrate in enzymatic assays for plasma cholesterol, aiding in the study and measurement of cholesterol levels in the blood.
Used in Ecological Studies:
Lathosterol has been used to supplement the diet of Daphnia galeata, a small freshwater crustacean, to study its effects on life-history traits. This application helps in understanding the ecological impact of cholesterol and its precursors on aquatic organisms.
Biochem/physiol Actions
5α-Cholest-7-en-3β-ol (Lathosterol) is an intermediate in cholesterol biosynthesis pathway. Lathosterol in serum is carried on lipoproteins and is indicative of the rate of cholesterol synthesis. It acts as a marker of synthesis of cholesterol and is not affected by dietary consumption of cholesterol.
Check Digit Verification of cas no
The CAS Registry Mumber 80-99-9 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 8 and 0 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 80-99:
(4*8)+(3*0)+(2*9)+(1*9)=59
59 % 10 = 9
So 80-99-9 is a valid CAS Registry Number.
InChI:InChI=1/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1
80-99-9Relevant articles and documents
Synthesis of a tritiated 3-dehydroecdysteroid putative precursor of ecdysteroid biosynthesis in Locusta migratoria
Dolle,Hetru,Roussel,Rousseau,Sobrio,Luu,Hoffmann
, p. 7067 - 7080 (2007/10/02)
We have synthesized a tritiated form of 14α-hydroxy-5β-cholest-7-ene-3,6-dione (5β-diketol) of high specific activity (1.74 TBq/mmol) from 7-dehydrocholesterol in seven steps with stereoselective introduction of the A/B cis ring junction as the key reaction. We have examined the ability of endocrine glands (prothoracic glands) of Locusta migratoria to use this molecule as a precursor of 3-dehydroecdysone and of ecdysone biosynthesis. A very efficient conversion of 5β-diketol to ecdysone and to 3-dehydroecdysone was monitored, which opens up new possibilities for the understanding of the role of 3-dehydro-compounds in ecdysteroid biosynthesis.
Investigation of the component reactions of oxidative sterol demethylation. Formation and metabolism of 3-ketosteroid intermediates.
Swindell,Gaylor
, p. 5546 - 5555 (2007/10/12)
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Hydroxy-steroids. IV. The preparation and spectra of steroid olefins.
Cragg,Davey,Hall,Meakins,Richards,Whateley
, p. 1266 - 1276 (2007/10/10)
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