80224-89-1

Basic information

• Product Name: 5-(4-chlorophenyl)-2-phenyl-1,3-oxazole
• Synonyms: 5-(4-chlorophenyl)-2-phenyl-1,3-oxazole
• CAS NO: 80224-89-1
• Molecular Weight: 255.703
• Mol File: 80224-89-1.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: 5-(4-chlorophenyl)-2-phenyl-1,3-oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-chlorophenyl)-2-phenyl-1,3-oxazole(80224-89-1)
• EPA Substance Registry System: 5-(4-chlorophenyl)-2-phenyl-1,3-oxazole(80224-89-1)

Safety Data

• Hazardous Substances Data: 80224-89-1(Hazardous Substances Data)

Upstream product

• 80225-01-0 5-p-chlorophenyl-2-phenyl-4-tosyl-2-oxazoline 
• 3282-33-5 1-(4-chlorophenyl)-2-diazoethanone 
• 100-47-0 benzonitrile 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 224566-03-4 5-(4-chlorobenzoyloxy)-3-phenylisoxazole 
• 59009-65-3 methyl N-(tosylmethyl)thiobenzimidate 
• 104-88-1 4-chlorobenzaldehyde 
• 20662-88-8 2-phenyloxazole 
• 637-87-6 1-Chloro-4-iodobenzene 
• 5468-33-7 1-(4-chlorophenyl)-2-nitroethan-1-one 
• 707-07-3 orthobenzoic acid trimethyl ester 
• 1073-67-2 4-vinylbenzyl chloride 
• 100-46-9 benzylamine 
• 1374963-89-9 N-[(Z)-2-(4-chlorophenyl)ethenyl]benzamide 

Relevant articles and documents

Divergent Conversion of N-Acyl-isoxazol-5(2 H)-ones to Oxazoles and 1,3-Oxazin-6-ones Using Photoredox Catalysis

The fragmentation of N-acyl-isoxazol-5-ones using visible light photoredox catalysis has been disclosed. The catalyst-controlled divergent mechanisms, namely the oxidative and reductive quenching catalytic cycle, are utilized. Various oxazoles and 1,3-oxazin-6-ones are selectively obtained from the same isoxazol-5-one skeleton under mild conditions.

Synthesis of 2,5-disubstituted oxazoles: Via cobalt(III)-catalyzed cross-coupling of N -pivaloyloxyamides and alkynes

An efficient synthesis of 2,5-disubstituted oxazoles via Co(iii) catalysis is described herein. The synthesis is achieved under mild conditions through [3+2] cycloaddition of N-pivaloyloxyamides and alkynes. The reaction operates through an internal oxidation pathway and features a very broad substrate scope. The one-step synthesis of natural products such as texamine and balsoxin has been demonstrated via this protocol.

Metal-Free sp3 C-H Functionalization: PABS/I2-Promoted Synthesis of Polysubstituted Oxazole Derivatives from Arylethanones and 2-Amino-2-alkyl/arylacetic Acid

A nonmetal-catalyzed process for the synthesis of polysubstituted oxazoles from inexpensive and readily available α-amino acids and methyl ketones is established. This reaction is proposed to achieve oxidative cleavage of C(sp3)-H bonds, followed by decarboxylation and annulation. The mild reaction conditions employed in both cases enable the tolerance of a wide range of functional groups as well as high reaction efficiency.