80307-12-6 Usage
Description
GMBS, also known as N-(γ-maleimidobutyryloxy)succinimide, is a heterobifunctional cross-linking reagent that contains both maleimide and amine reactive groups. It is a white solid and is commonly used to introduce maleimide groups into IgM and other biomolecules.
Uses
Used in Bioconjugation:
GMBS is used as a cross-linking reagent for bioconjugation, particularly for the attachment of proteins, peptides, and other biomolecules to each other or to solid supports. Its maleimide group reacts with thiol groups, while its amine reactive group can be used to modify amine-containing molecules.
Used in Enzyme Immunoassays:
GMBS is used as a heterobifunctional cross-linking reagent in enzyme immunoassays. Its amine and sulfhydryl reactivity make it useful for linking enzymes to antibodies or other molecules, improving the sensitivity and specificity of the assay.
Used in Drug Delivery Systems:
GMBS can be used in the development of drug delivery systems, where it can be employed to attach drug molecules to targeting ligands or nanoparticles, enhancing the delivery and efficacy of the therapeutic agents.
Used in Biosensor Development:
GMBS can be used in the fabrication of biosensors, where it can be employed to immobilize biological recognition elements, such as enzymes or antibodies, onto sensor surfaces, improving the performance and stability of the sensors.
Used in Protein Engineering:
GMBS can be used in protein engineering to introduce specific modifications or tags to proteins, enabling their detection, purification, or immobilization for various applications, such as affinity chromatography or surface plasmon resonance.
Used in Tissue Engineering:
GMBS can be used in tissue engineering to cross-link proteins or other biomolecules to scaffolds, promoting cell adhesion, growth, and tissue regeneration.
Used in Diagnostics:
GMBS can be used in the development of diagnostic tools, where it can be employed to attach signaling molecules or labels to antibodies or other recognition elements, improving the sensitivity and specificity of diagnostic assays.
Overall, GMBS is a versatile cross-linking reagent with a wide range of applications in various fields, including bioconjugation, enzyme immunoassays, drug delivery, biosensor development, protein engineering, tissue engineering, and diagnostics. Its unique combination of maleimide and amine reactive groups allows for the specific and efficient modification of a variety of biomolecules, making it a valuable tool in the development of new therapies, diagnostic tools, and research techniques.
Check Digit Verification of cas no
The CAS Registry Mumber 80307-12-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,3,0 and 7 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 80307-12:
(7*8)+(6*0)+(5*3)+(4*0)+(3*7)+(2*1)+(1*2)=96
96 % 10 = 6
So 80307-12-6 is a valid CAS Registry Number.
InChI:InChI=1/C12H12N2O6/c15-8-3-4-9(16)13(8)7-1-2-12(19)20-14-10(17)5-6-11(14)18/h3-4H,1-2,5-7H2
80307-12-6Relevant articles and documents
Synthesis of desmosine-BSA/KLH conjugates via Sonogashira/Negishi cross-coupling reactions
Miyagi, Seiya,Yokoo, Reiko,Tanigawa, Takahiro,Pitna, Dinda B.,Hirose, Mika,Usuki, Toyonobu
supporting information, (2022/01/14)
Desmosine is an elastin crosslinking amino acid that is expected to be a useful biomarker of diseases related to elastin degradation including chronic obstructive pulmonary disease (COPD). In this study, conjugates of desmosine and carrier proteins, such
CONJUGATES OF A CELL-BINDING MOLECULE WITH CAMPTOTHECIN ANALOGS
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Page/Page column 202, (2021/10/30)
Provided are conjugates of camptothecin analogs with a cell-binding molecule of formula (I), wherein R1, R2, R3, R4, R5, X, L, n, m, T and ----- are defined herein. It also provides methods of making the conjugates of camptothecin analogs to a cell-binding agent, as well as methods of using the conjugates in targeted treatment of cancer, infection, and immunological disorders.
A CONJUGATE OF A CYTOTOXIC AGENT TO A CELL BINDING MOLECULE WITH BRANCHED LINKERS
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Page/Page column 270, (2021/01/23)
Provided is a conjugation of cytotoxic drug to a cell-binding molecule with a side-chain linker. It provides side-chain linkage methods of making a conjugate of a cytotoxic molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and immunological disorders.
