81114-98-9Relevant articles and documents
New method for asymmetrically synthesizing natural product (-)-Euscapholide isomer
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Paragraph 0008; 0041; 0043, (2016/10/08)
The invention relates to a new method for asymmetrically synthesizing a natural product (-)-Euscapholide isomer. The method comprises the following steps: carrying out methoxybenzyl group protection on (R)-3-hydroxymethyl butyrate used as an initial raw material, reducing by using diisobutylaluminium hydride, carrying out a Mukaiyama aldol reaction, reducing by using sodium borohydride, carrying out ring closure under acidic conditions, eliminating hydroxyl groups, and deprotecting to complete asymmetric total synthesis of the target molecule 1. The method has the advantages of novel and reasonable synthesis route design, cheap and easily available raw material, simple operating process, mild reaction conditions, efficient completion of the asymmetric total synthesis of the Euscapholide isomer with two chiral centers, and single product configuration.
Total synthesis of (±)-bisabosqual A
Am Ende, Christopher W.,Zhou, Zhou,Parker, Kathlyn A.
supporting information, p. 582 - 585 (2013/03/13)
The synthesis of the novel squalene synthase inhibitor, bisabosqual A, was completed in 14 steps (longest linear sequence) from commercially available starting materials. The doubly convergent route employs a tandem 5-exo, 6-exo radical cyclization as the
Revision of the structure of alatinone to emodin
Kelly,Ma Zhenkun,Xu Wei
, p. 253 - 254 (2007/10/02)
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