81228-09-3 Usage
Description
2,4-Difluorophenylacetic acid is an organic compound characterized by the presence of two fluorine atoms at the 2nd and 4th positions on a phenyl ring, with an acetic acid group attached. This unique structure endows it with specific chemical properties that make it valuable in various applications.
Uses
Used in Pharmaceutical and Biochemical Research:
2,4-Difluorophenylacetic acid is used as a key intermediate in the synthesis of nonpolar peptide nucleic acid monomers containing fluoroaromatics (F-PNA). These F-PNA monomers are crucial for the development of new drugs and bioactive molecules, as they can enhance the stability, binding affinity, and specificity of PNA towards nucleic acids. This makes them promising candidates for applications in gene regulation, antisense therapy, and molecular recognition.
Used in Chemical Synthesis:
2,4-Difluorophenylacetic acid serves as a versatile building block in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and specialty chemicals. Its reactivity and the presence of fluorine atoms make it a valuable component in the design and synthesis of novel molecules with improved properties, such as increased lipophilicity, metabolic stability, and binding affinity.
Check Digit Verification of cas no
The CAS Registry Mumber 81228-09-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,2,2 and 8 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 81228-09:
(7*8)+(6*1)+(5*2)+(4*2)+(3*8)+(2*0)+(1*9)=113
113 % 10 = 3
So 81228-09-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H6F2O2/c9-6-2-1-5(3-8(11)12)7(10)4-6/h1-2,4H,3H2,(H,11,12)
81228-09-3Relevant articles and documents
Novel route for preparing dolutegravir key intermediate 2,4-difluorobenzylamine
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Paragraph 0026, (2018/11/22)
The invention discloses a production route which is concise and green in route, low in cost and easy to industrialize to prepare 2,4-difluorobenzylamine. The route comprises the following four steps:a) by taking m-difluorobenzene as an initial raw material, under catalysis of lewis acid, carrying out a Foucault alkylation reaction with ethylene oxide so as to prepare an intermediate 2,4-difluorobenzene ethanol; b) carrying out a second step of reactions on the product of the step a) without separation or purification, and oxidizing the 2,4-difluorobenzene ethanol to generate 2,4-difluorobenzene phenylacetic acid; c) enabling the product 2,4-difluorobenzene phenylacetic acid of the step b) with sulfoxide chloride and an ammonia gas to react so as to prepare 2,4-difluorophenylacetamide; d)under induction of bromine, enabling the product 2,4-difluorophenylacetamide of the step c) to react with a sodium hypochlorite solution, and carrying out Hofmann degradation, thereby obtaining a target product 2,4-difluorobenzylamine. The preparation method disclosed by the invention is simple and easy in raw material obtaining, concise in route, green and environmentally friendly, low in cost and easy in industrial production.
