81682-53-3

Basic information

• Product Name: oxo(propylamino)acetic acid
• Synonyms: 2-keto-2-propylamino-acetic acid;2-oxo-2-propylaminoacetic acid;2-oxo-2-propylamino-acetic acid;2-oxo-2-propylamino-ethanoic acid;oxo(propylamino)acetic acid;acetic acid, oxo(propylamino)-;Albb-009510;oxo(propylamino)acetic acid(SALTDATA: FREE)
• CAS NO: 81682-53-3
• Molecular Formula: C₅H₉NO₃
• Molecular Weight: 131.13
• Mol File: 81682-53-3.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Density: 1.174g/cm³
• Refractive Index: 1.456
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: oxo(propylamino)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: oxo(propylamino)acetic acid(81682-53-3)
• EPA Substance Registry System: oxo(propylamino)acetic acid(81682-53-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 81682-53-3(Hazardous Substances Data)

Usage

General Description

Oxo(propylamino)acetic acid is a chemical compound which is a derivative of propylamine and acetic acid. It is commonly used in the pharmaceutical industry as a precursor for the synthesis of various drugs, particularly those targeting the central nervous system. The compound has also been found to have potential applications in the treatment of neurological disorders, as it can modulate the activity of certain neurotransmitters in the brain. Oxo(propylamino)acetic acid is considered to be a valuable building block in the development of new therapeutic agents and is the subject of ongoing research for its potential pharmacological properties.

InChI:InChI=1/C5H9NO3/c1-2-3-6-4(7)5(8)9/h2-3H2,1H3,(H,6,7)(H,8,9)

Upstream product

• 107-10-8 propylamine 
• 79-37-8 oxalyl dichloride 
• 490-83-5 L-threo-2,3-hexodiulosono-1,4-lactone 
• 20943-65-1 ethyl 2-(propylamino)-2-oxoacetate 
• 95-92-1 oxalic acid diethyl ester 

Downstream Products

• 110-78-1 Propyl isocyanate 
• 14040-77-8 N,N'-dipropyloxamide 
• 1040762-67-1 C₁₈H₁₄BrClF₃N₃O₃ 

Relevant articles and documents

Oxamic acid analogues as LDH-C4-specific competitive inhibitors

We performed kinetic studies to determine whether oxamate analogues are selective inhibitors of LDH-C4, owing to their potential usefulness in fertility control and treatment of some cancers. These substances were shown to be competitive inhibitors of LDH isozymes and are able to discriminate among subtle differences that differentiate the active sites of LDH-A4, LDH-B4 and LDH-C4. N-Ethyl oxamate was the most potent inhibitor showing the highest affinity for LDH-C4. However, N-propyl oxamate was the most selective inhibitor showing a high degree of selectivity towards LDH-C4. Non-polar four carbon atoms chains, linear or branched, dramatically diminished the affinity and selectivity towards LDH-C4. N-Propyl oxamate significantly reduced ATP levels, capacitation and mouse sperm motility, in line with results shown by others, suggesting that LDH-C4 plays an essential role in mouse fertility.

Reactions of dehydroascorbic acid with primary aliphatic amines including Nα-acetyllysine

The reaction of L-dehydroascorbic acid (DHA) with primary aliphatic amines including Nα-acetyllysine was examined by HPLC. A new aminoreductone, 2-deoxy-2-(propylamino)ascorbic acid (1) was isolated and the structure elucidated by spectroscopic data. Furthermore oxalic acid mono-(2) and diamides (3) were identified as important degradation products of DHA under Maillard conditions. 3-Deoxy-3-(alkylamino)ascorbic acids (4), typical condensation products of L-ascorbic acid and amines, were also detected in the reaction mixtures of DHA. All products are formed under oxidative and nonoxidative conditions from DHA.

Reactivity of Carbamoyl Radicals. A New, General, Convenient Free-Radical Synthesis of Isocyanates from Monoamides of Oxalic Acid

A new, general, simple synthesis of isocyanates was developed by oxidation of monoamides of oxalix acid with peroxydisulfate catalyzed by Ag and Cu salts.The reaction was carried out in a two-phase system (water and an organic solvent), and it is suitable also for practical applications, due to the simple experimental conditions and the inexpensive as well as nontoxic reagents.The first example of homolytic intramolecular aromatic carbamoylation is also reported.