822-36-6 Usage
Description
2-Methylimidazole-4-sulfonic acid is a monosulfonated imidazole derivative that can be used as a building block in the preparation of a wide range of biologically active compounds. It is a product that results from the interaction of reducing sugars with ammonia and possesses unique chemical properties due to the presence of the methyl and sulfonic acid groups.
Uses
Used in Pharmaceutical Industry:
2-Methylimidazole-4-sulfonic acid is used as an intermediate in the synthesis of various pharmaceutical compounds, including the active pharmaceutical ingredient cimetidine. It contributes to the development of drugs with specific therapeutic properties.
Used in Chemical Synthesis:
2-Methylimidazole-4-sulfonic acid is used as a versatile building block in the synthesis of a variety of biologically active compounds. Its unique chemical structure allows for the creation of new molecules with potential applications in various fields.
Used in Antimicrobial Agents:
2-Methylimidazole-4-sulfonic acid can be used as a component in the development of antibacterial agents. Its chemical properties may contribute to the effectiveness of these agents in combating bacterial infections.
Preparation
4-Methylimidazole is synthesized by the reaction of glyoxal, acetaldehyde and ammonia. Another method to synthesize the compound is by catalytic dehydrogenation of imidazoline derivatives. 4-Methylimidazole may be synthesized from propanol and formamide, by catalytic cyclization of bisformamidipropane or by photolysis of alkenyltetrazole derived from alkenes by sequential epoxidation, ring opening and dehydration (NTP, 2007).
Purification Methods
Recrystallise 4-methylimidazole from *benzene or pet ether. It has m 56o after sublimation. The picrate has m 162-163.5o (from EtOH). [Beilstein 23 II 60, 23 III/IV 597, 23/5 V 89.]
Check Digit Verification of cas no
The CAS Registry Mumber 822-36-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,2 and 2 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 822-36:
(5*8)+(4*2)+(3*2)+(2*3)+(1*6)=66
66 % 10 = 6
So 822-36-6 is a valid CAS Registry Number.
InChI:InChI=1/C4H6N2/c1-4-2-5-3-6-4/h2-3H,1H3,(H,5,6)
822-36-6Relevant articles and documents
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Takeuchi et al.
, p. 3565,3566, 3567, 3569 (1978)
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METHOD FOR PRODUCING HETEROAROMATIC CARBOXYLIC ACID
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Paragraph 0039; 0045; 0046, (2018/08/09)
PROBLEM TO BE SOLVED: To provide a method for producing heteroaromatic carboxylic acids at good yields, when producing the heteroaromatic carboxylic acids by the oxidation of methyl-substituted heteroaromatic compounds. SOLUTION: A method for producing a heteroaromatic carboxylic acid includes oxidizing a methyl-substituted heteroaromatic compound, having one or more methyl groups on a heteroaromatic ring, with a basic compound and a permanganate. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT
Pd-catalyzed coupling reaction of fluorinated propargyl amidines with aryl iodides
Li, Shan,Yuan, Yafen,Li, Yajun,Li, Zhengke,Zhang, Lisi,Wu, Yongming
supporting information, p. 41 - 43 (2013/02/22)
Catalyzed by ligand free Pd(OAc)2, 2,5-disubstituted imidazole was prepared in good yield by the reaction of fluorinated propargyl amidines with iodoarene. Mechanistic studies indicated that this transformation occurs through a nitropalladation-reductive elimination pathway. The Royal Society of Chemistry.