82410-02-4Relevant articles and documents
Synthesis, 470-MHz 1H NMR Spectra, and Activity of Delactonized Derivatives of the Anticancer Drug Etoposide
Jardine, Ian,Strife, Robert J.,Kozlowski, John
, p. 1077 - 1081 (1982)
The anticancer drug etoposide (VP 16-213, 1) contains a highly strained trans-fused γ-lactone.This functionality is readily metabolized to an inactive ring-opened hydroxy acid (2).To prevent this detoxification of the drug and to investigate whether the l