83015-26-3Relevant articles and documents
Preparation method of N-methyl-3-(2-methylphenoxy)amphetamine
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Paragraph 0081-0092, (2021/09/04)
The invention discloses a preparation method of N-methyl-3-(2-methylphenoxy)amphetamine as shown in a formula III. The preparation method comprises the following step: in DMSO, (S)-N-methyl-3-(2-methylphenoxy)amphetamine as shown in a formula II and potassium tert-butoxide are subjected to racemization reaction to obtain the N-methyl-3-(2-methylphenoxy)amphetamine. Chiral N-methyl-3-(2-methylphenoxy)amphetamine is subjected to efficient racemization under mild conditions, no obvious impurities are generated, and the obtained racemization product can be further split to obtain required (R)-atomoxetine, so that the splitting efficiency of atomoxetine is improved.
Preparation method of atomoxetine hydrochloride
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, (2020/06/09)
The invention belongs to the technical field of medicines, and particularly relates to a preparation method of atomoxetine hydrochloride serving as a medicine for treating attention deficit hyperactivity. According to the invention, commercially available (E)-N-methyl-3-phenyl-2-propylene-1-amine is adopted as a starting material, and addition, substitution and salification are carried out so as to prepare atomoxetine hydrochloride. The preparation method provided by the invention is simple in preparation process, simple and convenient to operate, relatively high in yield and suitable for industrial production, and can provide sufficient bulk drugs for research and development of medicines.
Preparation method of atomoxetine
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Paragraph 0003; 0012; 0013, (2020/06/05)
The invention belongs to the technical field of medicines, and particularly relates to a preparation method of atomoxetine hydrochloride serving as a medicine for treating attention deficit hyperactivity. Commercially available 3-(methylamino)-1-phenylacetone is adopted as a starting material, and undergoes asymmetric reduction, substitution and other reactions to prepare the atomoxetine. The invention mainly aims to prepare the atomoxetine by an asymmetric synthesis method and expand a preparation method of the atomoxetine hydrochloride.