83470-22-8

Basic information

• Product Name: 2-Butanone, 4-phenyl-4-(2-pyridinyl)-
• CAS NO: 83470-22-8
• Molecular Formula: C15H15NO
• Molecular Weight: 225.29
• Mol File: 83470-22-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Butanone, 4-phenyl-4-(2-pyridinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butanone, 4-phenyl-4-(2-pyridinyl)-(83470-22-8)
• EPA Substance Registry System: 2-Butanone, 4-phenyl-4-(2-pyridinyl)-(83470-22-8)

Safety Data

• Hazardous Substances Data: 83470-22-8(Hazardous Substances Data)

Upstream product

• 94445-74-6 (E)-4-(pyridin-2-yl)but-3-en-2-one 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 1896-62-4 (E)-benzalacetone 
• 85311-89-3 2-pyridylcopper 
• 109-04-6 2-bromo-pyridine 
• 140-29-4 phenylacetonitrile 

Relevant articles and documents

2-Thienyl as Auxiliary Group in Mixed Lithium Diorganocuprate

2-Thienylcopper (ThCu) gives mixed lithium organothienylcuprate reagents (LiRThCu) with organolithium compounds (R = methyl, butyl, phenyl and 2-pyridyl) in ether.These cuprates react with enones or enoates adding the group R, 1,4 to the substrates, 2-thienylcopper being regenerated.The isolated yields of conjugate addition are substantial (40-89percent) and comparable to those obtained with LiR2Cu in corresponding addition.Since a mixed organothienylcuprates are rather stable at 0 deg C, and sometimes even at room temperature, the 2-thienyl group is an useful auxiliary in mixed lithium organocuprates for conjugate addition.Lithium bis(2-thienyl)cuprate, on the other hand, gives 1,2- as well as 1,4-addition of the 2-thienyl group to enones and to methyl crotonate.

CONJUGATE ADDITION WITH 2-PYRIDYLCOPPER AND LITHIUM 2-PYRIDYLCUPRATES

2-Pyridylcopper/dibutyl sulfide, 2-pyridylcopper/tributylphosphine, lithium di(2-pyridyl)cuprate and lithium (2-pyridyl)(phenyl)cuprate all add the 2-pyridyl group to 4-phenyl-3-buten-2-one in good yields.The cuprates also add the 2-pyridyl group to ethyl 3-phenypropenoate.