83830-88-0Relevant articles and documents
Stabilizing amyloid-β peptide by the N-terminus capture is capable of preventing and eliminating amyloid-β oligomers
Wen, Gesi,Chen, Daoyuan,Qin, Wenjing,Zhou, Binhua,Wang, Youqiao,Liu, Ziyi,Du, Jun,Zhou, Qiang,Quan, Junmin,Bu, Xianzhang
supporting information, p. 7673 - 7676 (2017/07/12)
Elimination of amyloid-β (Aβ) oligomers remains challenging. We describe here a novel strategy to prevent and eliminate the Aβ oligomers from either the early aggregation or the fibril dissolution pathway by targeting the flexible N-terminus, but not the widely investigated hydrophobic segment, with a rationally designed cyclopeptide.
