840-80-2

Basic information

• Product Name: Isonicotinic acid, (m-hydroxybenzylidene)hydrazide
• CAS NO: 840-80-2
• Molecular Formula: C₁₃H₁₁N₃O₂
• Molecular Weight: 241.249
• Mol File: 840-80-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.24g/cm³
• CAS DataBase Reference: Isonicotinic acid, (m-hydroxybenzylidene)hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Isonicotinic acid, (m-hydroxybenzylidene)hydrazide(840-80-2)
• EPA Substance Registry System: Isonicotinic acid, (m-hydroxybenzylidene)hydrazide(840-80-2)

Safety Data

• Hazardous Substances Data: 840-80-2(Hazardous Substances Data)

Upstream product

• 54-85-3 isoniazid 
• 100-83-4 meta-hydroxybenzaldehyde 

Downstream Products

• 1265227-83-5 C₁₅H₁₃N₃O₃ 
• 1265227-81-3 C₁₅H₁₂ClN₃O₃ 

Relevant articles and documents

Antimicrobial activities of synthetic arylidine nicotinic and isonicotinic hydrazones

Background: Despite availability of variety of antibacterial agents, re-emergance of pathogenic bacteria is still a serious medical concern. Identification of new, safer, and selective antibacterial agents is the key interest in the medicinal chemistry research. Methods: A library of synthetic arylidene nicotinic and isonicotinic hydrazones (1-63) were investigated for antimicrobial activities. Results: A number of derivatives showed significant to moderate antimicrobial activities against Gram positive and Gram negative bacterial cultures. Few compounds also showed antifungal activity against fungal cultures. Minimum Inhibitory Concentration (MIC) was calculated for the most active compounds 1, 7, 11, 19, 34, 46, 50, 51, and 55 against gram positive and gram negative cultures. Conclusion: Newly identified compounds may serve as lead for future research in order to get the more powerful antibacterial agents.

MFA zeotype catalyst: A greener approach for the synthesis of INH azomethine scaffolds

Herein, we are reporting the green and efficient synthesis of some pharmacologically important azomethine derivatives of isoniazide (INH) using Modified Fly Ash (MFA) as an excellent zeotic solid acid catalyst. The catalyst, by virtue of its terminal hydr

Synthesis and anti-mycobacterial activity of (E)-N′-(monosubstituted-benzylidene)isonicotinohydrazide derivatives

A series of 22 (E)-N′-(monosubstituted-benzylidene)isonicotinohydrazide derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using Alamar Blue susceptibility test and