84194-36-5

Basic information

• Product Name: 2-Chloro-4-fluorobenzaldehyde
• Synonyms: TIMTEC-BB SBB003983;2-CHLORO-4-FLUOROBENZALDEHYDE;2-Chloro-4-Flouorobenzaldehyde;2-Chloro-4-fluorobenzaldehyde 97%;2-Chloro-4-fluorobenzaldehyde97%;2-Chloro-4-fluorobenzaldehyde ,98%
• CAS NO: 84194-36-5
• Molecular Formula: C₇H₄ClFO
• Molecular Weight: 158.56
• Product Categories: Fluorin-contained benzaldehyde series;Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde;Fluorobenzene;Miscellaneous;Adehydes, Acetals & Ketones;Chlorine Compounds;Fluorine Compounds;Aldehydes;C7;Carbonyl Compounds;Azaindoles
• Mol File: 84194-36-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 60-63 °C(lit.)
• Boiling Point: 118-120 °C50 mm Hg(lit.)
• Flash Point: >110°C
• Appearance: white to slightly yellow crystalline
• Density: 1.3310 (estimate)
• Storage Temp.: Refrigerator
• Sensitive: Air Sensitive
• BRN: 3537704
• CAS DataBase Reference: 2-Chloro-4-fluorobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-fluorobenzaldehyde(84194-36-5)
• EPA Substance Registry System: 2-Chloro-4-fluorobenzaldehyde(84194-36-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 84194-36-5(Hazardous Substances Data)

Usage

Description

2-Chloro-4-fluorobenzaldehyde is an organic compound characterized by the presence of a chlorine atom at the 2nd position and a fluorine atom at the 4th position on a benzene ring, with an aldehyde functional group attached to the 1st position. This molecule exhibits unique chemical properties due to the presence of both electron-withdrawing and electron-donating substituents, making it a versatile intermediate in organic synthesis.

Uses

Used in Pharmaceutical Industry:
2-Chloro-4-fluorobenzaldehyde is used as a reactant in the regioand stereoselective preparation of spiro[pyrrolidinoxindoles], which are important structural motifs in the development of pharmaceutical compounds with potential therapeutic applications.
Used in Chemical Synthesis:
2-Chloro-4-fluorobenzaldehyde may be used in the synthesis of substituted α-cyanocinnamic acid through the Knoevenagel condensation reaction. This reaction is a key step in the preparation of various organic compounds, including dyes, pigments, and pharmaceuticals.
Used in Organic Chemistry Research:
2-Chloro-4-fluorobenzaldehyde is used in the synthesis of 2-(2-benzimidazolyl)-3-(2-chloro-4-fluorophenyl)acrylonitrile, a compound of interest in organic chemistry research. This molecule can serve as a building block for the development of new materials and compounds with potential applications in various fields, such as electronics, materials science, and pharmaceuticals.

InChI:InChI=1/C7H4ClFO/c8-7-3-6(9)2-1-5(7)4-10/h1-4H

Upstream product

• 452-73-3 2-chloro-4-fluorotoluene 
• 459-57-4 4-fluorobenzaldehyde 
• 93286-22-7 2‐chloro‐4‐fluorobenzyl chloride 
• 208186-84-9 (2-chloro-4-fluorophenyl)methanol 
• 167758-87-4 ethyl 2-chloro-4-fluorobenzoate 
• 112135-96-3 2-chloro-4-fluorobenzal bromide 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 45767-66-6 2-chloro-4-fluorobenzylbromide 

Downstream Products

• 698356-74-0 2-chloro-4-(2-chloro-4-methoxy-phenoxy)-benzaldehyde 
• 698356-65-9 2-chloro-4-(3-chloro-4-methoxy-phenoxy)-benzaldehyde 
• 89883-24-9 11-fluorobenzofluoranthene 
• 753926-06-6 (2-chloro-4-fluoro-phenyl)-(1-isobutyl-1H-indazol-5-yl)-methanol 
• 516481-15-5 2-[2-Chloro-4-(4-chloro-phenoxy)-phenyl]-1H-benzoimidazole-5-carboxylic Acid Amide 
• 445478-78-4 N-[2-[[(1S,2S)-2-[[(2-Chloro-4-fluorophenyl)methyl]amino]cyclohexyl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide 
• 915100-54-8 2-chloro-4-fluoro-1-[(E)-2-nitrovinyl]benzene 
• 112108-68-6 1-(2-chloro-4-fluorophenyl)ethan-1-ol 
• 99329-85-8 2-chloro-4-fluoro-5-nitro-benzaldehyde 
• 101349-95-5 2-chloro-4-(methylsulfonyl)benzaldehyde 
• 947410-61-9 N-{4-[(2-chloro-4-fluorophenyl)(hydroxy)methyl]pyridin-3-yl}-2,2-dimethyl-propanamide 
• 823188-81-4 N-methyl-N-(2-chloro-4-fluorobenzyl)amine 
• 219764-82-6 2-chloro-4-((2-(N-methyl-N-(2-pyridinyl)amino)ethyl)oxy)benzaldehyde 
• 907186-39-4 2-chloro-4-fluoro-α-[(2-methylpropyl)amino]benzene-acetonitrile 

Relevant articles and documents

Preparation method of 2-chloro-4-fluoro-5-nitrobenzaldehyde

The invention belongs to the field of organic synthesis, and particularly relates to a preparation method of 2-chloro-4-fluoro-5-nitrobenzaldehyde. The method comprises the following steps: taking 2-chloro-4-fluorotoluene as a raw material, introducing ch

TEMPO-mediated oxidation of primary alcohols to aldehydes under visible light and air

A homogeneous visible light photoredox TEMPO-mediated selective oxidation of primary alcohols to the corresponding carbonyl compounds was developed using molecular oxygen from air as the terminal oxidant. Ru(bpy)3(PF 6)2 (bpy: bipyridyl) and Ir(dtb-bpy)(ppy) 2(PF6) (dtb-bpy: 4,4′-di-tert-butyl-2,2′- bipyridyl; ppy: 2-phenylpyridine) were used as the sensitizers. A homogeneous visible light photoredox TEMPO-mediated selective oxidation of primary alcohols to the corresponding carbonyl compounds was developed. Molecular oxygen from air was the terminal oxidant. Copyright

'HALEX' FLUORINATION OF CHLORINATED BENZALDEHYDES AND BENZOYL CHLORIDES

Spray-dried potassium fluoride, suspended in sulpholane at 220 degC, converted 2,4- and 2,6-dichlorobenzaldehyde into the corresponding difluoroaldehydes (yields ca. 65percent).Small amounts of the mono-substituted products (2-chloro-4-fluoro- + 4-chloro-2-fluorobenzaldehyde, and 2-chloro-6-fluoro-benzaldehyde, respectively) were also produced.Similar treatment of the 3,4-dichloro-analogue gave 3-chloro-4-fluorobenzaldehyde (yield 98percent, conversion 68percent), but 2- and 4-chlorobenzaldehyde gave very poor yields (ca. 5percent) of the 2- and 4-fluoro-derivatives. 2-Fluoro-, 4-fluoro- and 3-chloro-4-fluorobenzoyl fluoride were obtained (yields 60-65percent) by heating the corresponding chlorobenzoyl chlorides with potassium fluoride in sulpholane.