84467-85-6 Usage
Description
N-Formyl N,N-Didesmethyl Sibutramine is an intermediate metabolite of Sibutramine, a serotonin and noradrenaline reuptake inhibitor (SNR). It is a white solid with chemical properties that contribute to its role in the metabolism of Sibutramine.
Uses
Used in Pharmaceutical Industry:
N-Formyl N,N-Didesmethyl Sibutramine is used as an intermediate in the synthesis of Sibutramine for its pharmacological effects. It plays a role in the metabolism of Sibutramine, which is utilized as an appetite suppressant and weight loss medication. N-Formyl N,N-Didesmethyl Sibutramine helps decrease calorie intake and increase energy expenditure, making it a valuable component in the development of weight management therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 84467-85-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,4,6 and 7 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 84467-85:
(7*8)+(6*4)+(5*4)+(4*6)+(3*7)+(2*8)+(1*5)=166
166 % 10 = 6
So 84467-85-6 is a valid CAS Registry Number.
InChI:InChI=1/C16H22ClNO/c1-12(2)10-15(18-11-19)16(8-3-9-16)13-4-6-14(17)7-5-13/h4-7,11-12,15H,3,8-10H2,1-2H3,(H,18,19)
84467-85-6Relevant articles and documents
First practical synthesis of enantiomerically pure (R)- and (S)-desmethylsibutramine (DMS) and unambiguous determination of their absolute configuration by single-crystal X-ray analysis
Han, Zhengxu,Krishnamurthy, Dhileepkumar,Pflum, Derek,Fang, Qun K.,Butler, Hal,Cameron,Wald, Stephen A.,Senanayake, Chris H.
, p. 107 - 109 (2007/10/03)
A practical synthesis of enantiomerically pure (R)-desmethylsibutramine [(R)-DMS] and (S)-desmethylsibutramine [(S)-DMS] is outlined along with an improved synthesis of racemic desmethylsibutramine. This route was used for kilo-scale production of enantio
A study and identification of potential by-products of sibutramine
Reddy, G. Om,Sarma,Chandrasekhar,Babu, J. Moses,Prasad,Raju, C.M. Haricharan
, p. 488 - 492 (2013/09/08)
In the synthesis and process development of sibutramine (9), the isolation and characterization of two potential by-products namely heptane dinitriles (4a-b) and bis-cyclobutyl alkylamine (10) have been studied. The key steps in the synthesis of sibutramine which have contributed to the formation of above by-products are cycloalkylation of 4-chlorophenyl acetonitrile (1) and tandem Grignard reduction on 1-(4-chlorophenyl)cyclobutyl carbonitrile (3).